国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (6): 677-679.

• 论著 • 上一篇    下一篇

绝经前、后子宫内膜息肉组织中Bcl-2，BAG-1，Ki-67，ER和PR的表达及临床意义

郭慧梅，高希焕，陆颖仪，冯文栋，王燕燕   

  1. 528000 广东省佛山市，广东省中西医结合医院（郭慧梅，高希焕，陆颖仪，冯文栋）；广东医学院附属厚街医院（王燕燕）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-12-15 发布日期:2014-12-15

Expression and Clinical Significance of Bcl-2，BAG-1，Ki-67，ER and PR on Premenopausal and Postmenopausal Endometrial Polyps

GUO Hui-mei，GAO Xi-huan，LU Ying-yi， FENG Wen-dong，WANG Yan-yan   

  1. Guangdong Province Hospital of Combination of Traditional Chinese and Western Medicine，Foshan 528000，China（GUO Hui-mei，GAO Xi-huan，LU Ying-yi， FENG Wen-dong）；Houjie Hospital Affiliated to Guangdong Medical College，Dongguan 523945，China（WANG Yan-yan）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-12-15 Online:2014-12-15

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摘要： 目的：探讨B淋巴细胞瘤2（Bcl-2），Bcl-2结合抗凋亡基因1（BAG-1），Ki-67，雌激素受体（ER）和孕激素受体（PR）在绝经前、后子宫内膜息肉（EP）中的表达及其临床意义。方法：免疫组织化学（SP）法检测30例绝经前和30例绝经后患者EP组织Bcl-2，BAG-1，Ki-67，ER和PR表达并分析其临床意义。结果：EP组织中Bcl-2、BAG-1和Ki-67的表达高于对照组，差异有统计学意义（P＜0.05）；但ER和PR在2组中的表达差异无统计学意义（均P＞0.05）。绝经后EP组织中Ki-67的表达低于绝经前，差异有统计学意义（P＜0.05）；但绝经前、后EP组织中Bcl-2，BAG-1，ER和PR表达差异均无统计学意义（均P＞0.05）。绝经后EP组织Ki-67与PR呈正相关（P＜0.05），其他各组间均无相关性（均P＞0.05）。结论：Bcl-2，BAG-1，Ki-67，ER和PR可能在EP的病理改变的不同时段中发挥重要作用。

关键词: 子宫内膜息肉, B淋马细胞瘤-2, 雌激素, 孕激素类, Bcl-2结合抗体凋亡基因1

Abstract: Objective：To stduy the expression and clinical significance of Bcl-2，BAG-1，Ki-67，ER and PR on premenopausal and postmenopausal endometrial polyps. Methods：The expression of Bcl-2，BAG-1，Ki-67，ER and PR in 30 cases premenopausal endometrial polyps and 30 cases postmenopausal endometrial polyps tissues were detected by immunohistochemistry. Results：Bcl-2，BAG-1 and Ki-67 were higher expression in endometrial polyps than control group（P＜0.05），but no signification difference among ER and PR expression（P＞0.05）. Ki-67 expression in postmenopausal endometrial polyps was significantly lower than premenopausal endometrial polyps tissues（P＜0.05）. There were no signification difference among Bcl-2，BAG-1，ER and PR expression between premenopausal and postmenopausal endometrial polyps（P＞0.05）. Correlation analysis showed that Ki-67 was positively correlated with PR on postmenopausal endometrial polyps（P＜0.05），and there was no correlation among other groups（P＞0.05）. Conclusions：Bcl-2，BAG-1，Ki-67，ER and PR may play an important role at different period of endometrial polyps pathological changes.

Key words: Endometrial polyps, B-cell lymphoma-2, Estrogen, Progestins, Bcl-2-associated athanogene 1