国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (3): 260-264.

• 综述 • 上一篇    下一篇

黏液性卵巢癌的诊治进展

吴珈悦，狄文   

  1. 200127 上海交通大学医学院附属仁济医院妇产科， 上海市妇科肿瘤重点实验室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-06-15 发布日期:2015-06-15
  • 通讯作者: 狄文

The Advancement of Diagnosis and Treatment in Mucinous Epithelial Ovarian Cancer

WU Jia-yue，DI Wen   

  1. Department of Obstetrics and Gynecology，Ren Ji Hospital，School of Medicine，Shanghai Jiao Tong University，Shanghai Key Laboratory of Gynecologic Oncology，Shanghai 200127，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-06-15 Online:2015-06-15
  • Contact: DI Wen

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摘要： 黏液性卵巢癌（mEOC）是上皮性卵巢癌的一个特殊亚型，有其特有的生物学特性。其多为单侧性体积较大的盆腔肿块、发病率低、淋巴结转移率低、对铂类耐药、晚期预后差，并且有其特有的基因突变谱：KRAS基因突变率高，p53及乳腺癌易感基因（BRCA）突变率低。这些独特性使之在临床诊疗方面与其他上皮性卵巢癌有所不同。在临床分期早期的年轻患者中允许保留外观正常的子宫和对侧附件以保留其生育功能，并且若术中阑尾外观正常，且无腹膜假黏液性瘤证据时，不需行阑尾切除术。奥沙利铂与5-氟尿嘧啶联合应用可作为mEOC药物治疗的新方向。

关键词: 卵巢肿瘤, 腺癌, 黏液, 肿瘤, 腺和上皮, 诊断, 治疗

Abstract: Mucinous epithelial ovarian cancer（mEOC），as a special subtype of epithelial ovarian cancers，has its own unique characteristics，including low incidence of primary mEOC，unilaterality，large size，low rate of lymphatic metastases，platinum resistance，worse prognosis in advanced stage，and distinct mutational profiles，as KRAS mutations are common，but p53 and BRCA mutations are infrequent. These characteristics lead to specific guide in clinical management. In apparent early stage disease，fertility preservation is allowed by the conservation of the normal appearing uterus and contralateral ovary. Appendectomy is not essential as long as the appendix appears normal and there is no evidence of pseudomyxoma peritonei. New directions include the combination use of Oxaliplatin and 5-FU in chemotherapy.

Key words: Ovarian neoplasms, Adenocarcinoma, mucinous, Neoplasms, glandular and epithelial, Diagnosis