国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (5): 583-587.

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长链非编码RNA在宫颈癌中的研究进展

苏冠男，王冬亮，王武亮，朱前勇   

  1. 450000 郑州大学第二附属医院妇产科（苏冠男，王冬亮，王武亮）；中国人民解放军153中心医院（朱前勇）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-10-15 发布日期:2015-10-15
  • 通讯作者: 朱前勇

Research Progress of Long Non-coding RNAs in Cervical Cancer

SU Guan-nan，WANG Dong-liang，WANG Wu-liang，ZHU Qian-yong   

  1. Department of Obstetrics and Gynecology，The Second Affiliated Hospital of Zhengzhou University，Zhengzhou 450000，China（SU Guan-nan，WANG Dong-liang，WANG Wu-liang）；The Chinese People′s Liberation Army 153 Center Hospital，Zhengzhou 450000，China（ZHU Qian-yong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-10-15 Online:2015-10-15
  • Contact: ZHU Qian-yong

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摘要： 长链非编码RNA（long non-coding RNA，lncRNA）是一类长度超过200个核苷酸，无蛋白质编码功能的RNA分子，可在转录、转录后及表观遗传学等多个水平参与基因的表达调控，影响细胞的生长、发育、增殖、分化、代谢和凋亡等重要生理过程。越来越多的证据表明lncRNA与宫颈癌的发生发展密切相关，在肿瘤细胞凋亡调控、肿瘤浸润与转移等过程中发挥着促癌或抑癌作用，有望成为宫颈癌诊断及治疗中的新型分子标记物和治疗靶点。结合国内外最新报道，近年发现的与宫颈癌促癌作用相关的lncRNAs主要有HOX转录反义RNA（HOTAIR）、肺腺癌转移相关转录子1（MALAT1）、H19、EBIC、Linc-p21和脑细胞质200（BC200），与宫颈癌抑癌作用有关的lncRNAs主要有母系印迹基因3（MEG3）和XLOC_010588，改变其表达水平对宫颈癌细胞系的增殖、侵袭等生物学行为有明显影响，与宫颈癌临床病理因素密切相关，影响疾病预后。

关键词: 长链非编码RNA, 宫颈肿瘤, 基因, 肿瘤抑制

Abstract: Long non-coding RNAs (lncRNAs) are a group of RNA molecules which are longer than 200 nucleotides and they cannot encode proteins. Recent studies have demonstrated that lncRNAs are widely involved in the regulation of gene expression network at transcriptional, post-transcriptional and epigenetic levels, which may affect growth, proliferation, differentiation, metabolism, apoptosis and other important physiological processes of cells. In cervical cancer, lncRNA may act as the tumor promoter or tumor suppressor. It is becoming evident that lncRNAs may be an important class of pervasive genes involved in the regulation of multiple cellular biological processes, including apoptosis, tumor invasion and metastasis. lncRNA is hopefully to become the new type of molecular marker and therapeutic target in the diagnosis and treatment of cervical cancer. Combined with domestic and foreign latest reports, there are mainly six lncRNAs may have the role of carcinogenesis: HOX transcription antisense RNA (HOTAIR), lung adenocarcinoma metastasis related transcripts 1 (MALAT1), H19, EBIC, Linc-p21 and brain cell mass(BC200), and mainly two lncRNAs may have the function of cervical cancer suppressor: maternal imprinted genes 3 (MEG3) and XLOC_010588, changing their expression levels of cells may has an obvious effect on the mutiple biological behaviors such as cell proliferation, invasion. Moreover, they are closely associated with clinical pathologic factors of cervical cancer and influence the prognosis of disease.

Key words: Long non-coding RNAs, Uterine cervical neoplasms, Genes, tumor suppressor