国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (5): 594-596.

• 论著 • 上一篇    下一篇

监测上皮性卵巢癌患者术后血清HE4和CA125水平的价值

陈戴娣，陈寒凌，刘彩芬   

  1. 516001 广东省惠州市惠城区中医医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-10-15 发布日期:2015-10-15
  • 通讯作者: 陈戴娣

The Value of Monitoring Serum HE4 and CA125 after Surgery of Epithelial Ovarian Cancer

CHEN Dai-di，CHEN Han-ling，LIU Cai-fen   

  1. Department of Obstetrics and Gynecology，Huizhou Hospital of Traditional Chinese Medicine，Huizhou 516001，Guangdong Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-10-15 Online:2015-10-15
  • Contact: CHEN Dai-di

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摘要： 目的：探讨监测血清人附睾蛋白4（HE4）、糖类抗原125（CA125）水平变化在卵巢癌术后疗效评估中的应用价值。方法：应用电化学发光法随访34例上皮性卵巢癌（epithelial ovarian cancer，EOC）患者手术后1周、1个月、3个月、6个月HE4、CA125水平，并与手术前进行比较，同时将术后病情发展情况与对应的HE4、CA125水平变化进行比较。结果：EOC患者术前血清的HE4、CA125水平均高于健康对照组（P＜0.01）；手术后病情缓解患者27例，其术后1周、1个月、3个月、6个月的HE4、CA125水平均低于术前，差异有统计学意义（P＜0.01）；随着术后时间的延长，HE4、CA125水平不断降低，差异有统计学意义（P＜0.012 5）；术后病情继续进展患者7例，其HE4和CA125水平术后1周和术后1个月降低，差异有统计学意义（P＜0.05）；联合HE4和CA125水平与手术后EOC病情发展趋势符合率为85.3%。结论：联合检测HE4 和CA125对EOC手术后疗效评估、监测病情发展有重要临床价值。

关键词: 卵巢肿瘤, 蛋白质类, CA-125抗原, 肿瘤标记, 生物学

Abstract: Objective：To explore the application value of serum HE4 and CA125 level changes in the assessment of curative effect in ovarian cancer. Methods：HE4 and CA125 levels of 34 patients suffering from epithelial ovarian cancer （ＥＯＣ） were measured by electrochemiluminescence in one week，one month, three months and six months after surgery and compared with the corresponding values before surgery. The relevance between disease progression after surgery and the corresponding changes of HE4 and CA125 levels was compared. Results：HE4 and CA125 levels in serum of EOC patients were significantly higher than the control group（Ｐ＜０．０１）. In 27 remission cases, HE4 and CA125 values in one week, one month, three months and six months after surgery were significantly lower than before surgery（Ｐ＜０．０１）. The concentration of two markers were decreasing as the extension of time after surgery（Ｐ＜０．０１２ ５）. HE4 and CA125 levels showed statistical difference in 7 postoperative deterioration cases in one week and one month after the surgery （Ｐ＜０．０５）. Joint detection of HE4 and CA125 can elevate the coincidence rate to 85.3%. Conclusions：Simultaneous detection of HE4 and CA125 may have important value of clinical efficacy evaluation and monitoring of disease after EOC surgery.

Key words: Ovarian neoplasms, Proteins, CA-125 antigen, Tumor markers, biological