国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (5): 597-600.

• 讲座 • 上一篇    

早期子宫内膜癌的辅助治疗

王东雁，卢淮武，林少丹，林仲秋   

  1. 510120 广州，中山大学孙逸仙纪念医院妇瘤科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-10-15 发布日期:2015-10-15

Adjuvant Therapy in Early Stage Endometrial Cancer

WANG Dong-yan，LU Huai-wu，LIN Shao-dan，LIN Zhong-qiu   

  1. Department of Gynecology Oncology，Sun Yat-sen Memorial Hospital，Sun Yat-sen University，Guangzhou 510120，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-10-15 Online:2015-10-15

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摘要： 尽管早期子宫内膜癌预后良好，部分患者术后仍可能复发或转移。根据复发高危因素选择理想的术后辅助治疗，是目前临床上亟需解决的问题。对1990—2013年公开发表的Ⅲ期临床试验进行总结，评价各种辅助治疗在早期子宫内膜癌中的作用。对低危复发风险者，术后观察是适合的；对于中危复发风险者，阴道近距离照射也许是更好的选择；而对于高危复发风险者，盆腔外照射控制复发及改善生存率的效果还不理想，化疗在这一类患者中的作用尚在研究中。

关键词: 子宫内膜肿瘤, 癌, 化学疗法, 辅助, 近距离放射疗法, 临床试验, Ⅲ期

Abstract: Despite the good prognosis of early stage endometrial cancer, a part of patients will experience localized disease relapse or distant metastasis following surgery. It is to be solved that how to choose the ideal adjuvant therapy according to the high risk factors. This article conducted a review for Ⅲ phase clinical trials on record during 1990—2013, to evaluate the efficacy and safety of different adjuvant therapies in patient with early stage endometrial cancer. Post-surgical observation is appropriate for low risk patients; brachytherapy may be a better choice for intermediate risk patients; while for high risk patients, external beam radiotherapy is not effective enough in local relapse control and survival rate improvement, and the efficacy of adjuvant chemotherapy is still in study.

Key words: Endometrial neoplasms, Carcinoma, Chemotherapy, adjuvant, Brachytherapy, Clinical trial