国际妇产科学杂志

国际妇产科学杂志 ›› 2016, Vol. 43 ›› Issue (1): 103-106.

• 论著 • 上一篇    下一篇

绝经后女性同型半胱氨酸、脂质水平、CRP、NLR与骨质减少的关系

刘文华，汤珊珊，黄哲人，魏双双，张治芬，陈临节   

  1. 310006 杭州，南京医科大学附属杭州医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-02-15 发布日期:2016-02-15
  • 通讯作者: 张治芬

Relationship between Homocysteine, Lipid, CRP, NLR Levels and Osteopenia in Postmenopausal Women

LIU Wen-hua，TANG Shan-shan，HUANG Zhe-ren，WEI Shuang-shuang，ZHANG Zhi-fen，CHEN Lin-jie   

  1. Department of Obstetrics and Gynecology，Hangzhou Hospital of Nanjing Medical University，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-02-15 Online:2016-02-15
  • Contact: ZHANG Zhi-fen

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5626

被引次数

12

摘要： 目的：探究绝经后女性同型半胱氨酸（HCY）、C反应蛋白（CRP）、中性粒细胞/淋巴细胞比值（NLR）、脂质水平与骨质减少的关系。方法：收集2013年1月—2014年12月于南京医科大学附属杭州医院妇科门诊就诊的绝经后女性患者269例，年龄45～60岁，均未应用绝经期激素治疗。骨密度采用双能X线吸收测定法（DXA）测量，根据测定结果将受试者分为骨质正常组（n=128）和骨质减少组（n=141）。HCY采用酶联免疫吸附法测定，CRP、脂质指标采用化学发光免疫分析法测定。结果：骨质减少组绝经时间及血清低密度脂蛋白（LDL）、CRP、HCY、NLR水平高于骨质正常组，绝经年龄低于骨质正常组，差异有统计学意义（均P＜0.05）。绝经年龄晚是骨质减少的保护因素，绝经时间长及血清LDL、CRP、HCY、NLR水平升高是骨质减少的危险因素，OR（95%CI）分别为0.755（0.623～0.914），1.408（1.043~1.901），1.038（1.018~1.058），1.398（1.115~1.753），3.534（2.355~5.303）和3.959（2.148~7.299），差异有统计学意义（均P＜0.05）。结论：绝经年龄、绝经时间及血清LDL、CRP、HCY、NLR水平可作为绝经后女性骨质丢失的评价指标。

关键词: 骨质疏松, 绝经后, 脂质体, C反应蛋白质, 中性白细胞, 淋巴细胞, 同型半胱氨酸

Abstract: Objective：To explore the relationship between homocysteine, lipid levels, CRP, NLR and Osteopenia in postmenopausal women. Methods：We collected 269 postmenopausal women from Gynecological Clinic of Hangzhou Hospital of Nanjing Medical University, who aged 45 to 60 years old, never used menopause hormone therapy. According to the bone mineral density(BMD) determination results subjects were divided into normal group (n=128) and osteopenia group (n=141). BMD was measured by dual-energy X-ray absorptiometry (DXA). Homocysteine were measured by enzyme chemiluminescence immunoassay. CRP and lipid indexes using chemiluminescence immunoassay. Results：There were significant differences between the two groups in menopause age, duration of menopause and serum levels of LDL, CRP, HCY and NLR(P＜0.05). Menopausal age, duration of menopause, LDL, CRP, HCY and NLR are risk factors in postmenopausal women with osteopenia. The odds ratios and 95% confidence intervals of those variables were found to have significant difference between the two groups(P＜0.01), and were as follows 0.755（0.623～0.914），1.408（1.043~1.901），1.038（1.018~1.058），1.398（1.115~1.753），3.534（2.355~5.303） and 3.959（2.148~7.299）. Conclusions：Menopausal age, duration of menopause, serum levels of LDL, CRP, HCY and NLR can be used as the evaluation index of bone loss in postmenopausal women.

Key words: Osteoporosis, postmenopausal, Liposomes, C-reactive protein, Neutrophils, Lymphocytes