国际妇产科学杂志

国际妇产科学杂志 ›› 2017, Vol. 44 ›› Issue (1): 35-39.

• 综述 • 上一篇    下一篇

肿瘤干细胞与子宫内膜癌的关系的研究进展

陈勍1,邹雅婷2   

  1. 1. 中山大学附属第二院
    2. 中山大学孙逸仙纪念医院
  • 收稿日期:2016-08-15 修回日期:2016-11-02 出版日期:2017-02-15 发布日期:2017-03-28
  • 通讯作者: 陈勍 E-mail:sumsqing@139.com

The progress of the relationship between cancer stem cells and Endometrial cancer.

Ya-Ting zou2   

  • Received:2016-08-15 Revised:2016-11-02 Published:2017-02-15 Online:2017-03-28

PDF (PC)

7002

摘要： 子宫内膜癌是妇科常见的三大恶性肿瘤之一，其发病率近年来呈上升趋势，严重威胁女性健康。肿瘤干细胞是一类具有自我更新、无限增殖、多向分化潜能及高致瘤性的肿瘤细胞亚群。现大量的研究证实肿瘤干细胞在子宫内膜癌的发生、发展、转移及复发中起着关键作用，可能是导致子宫内膜癌治疗失败的原因。此文就肿瘤干细胞的特性、来源及其与子宫内膜癌相关特殊表面标志物的研究作一综述。

关键词: 子宫内膜癌, 肿瘤干细胞, 表面标记物, 诊断与治疗

Abstract: Endometrial carcinoma, which is one of the most common gynecologic malignant tumors, severely threatens women’s health, and its incidence is showing an increasing trend in recent years. Cancer stem cells are defined as a subset of cancer cells with abilities of self-renewal, unlimited proliferation, multipotential differentiation and high tumorigenicity. Current emerging evidences indicate that the cancer stem cells are likely responsible for the development, progression, metastasis and recurrence of endometrial carcinoma. These may be the main reasons for the poor prognosis. This review is a conclusion of the sources and characters of cancer stem cells, and their special surface markers in endometrial carcinoma.

Key words: endometrial cancer, cancer stem cells, surface markers, diagnosis and treatment