国际妇产科学杂志

国际妇产科学杂志 ›› 2017, Vol. 44 ›› Issue (2): 125-128.

• 综述 •    下一篇

表观遗传学与卵巢癌耐药的关系研究

陈家烨，费菁，周建维   

  1. 310058  杭州，浙江大学医学院（陈家烨）；浙江大学医学院附属第二医院妇科（费菁，周建维）
  • 收稿日期:2016-09-26 修回日期:2016-11-26 出版日期:2017-04-15 发布日期:2017-05-18
  • 通讯作者: 周建维 E-mail:zhou_jianwei@126.com
  • 基金资助:
    国家自然基金面上项目;浙江省自然基金面上项目

Study on the Relationship between Epigenetic and Drug Resistance in Ovarian Cancer

CHEN Jia-ye，FEI Jing，ZHOU Jian-wei   

  1. School of Medicine，Zhejiang University，Hangzhou 310058，China（CHEN Jia-ye）；Department of Gynecology，The Second Affiliated Hospital of Zhejiang University School of Medicine，Hangzhou 310009，China（FEI Jing，ZHOU Jian-wei）
  • Received:2016-09-26 Revised:2016-11-26 Published:2017-04-15 Online:2017-05-18
  • Contact: jianwei zhou E-mail:zhou_jianwei@126.com

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被引次数

1

摘要： 卵巢癌是最常见的三大女性生殖器恶性肿瘤之一，其致死率居妇科恶性肿瘤首位。研究表明肿瘤的发生、发展及其耐药机制与表观遗传学有着密切的联系，而相关研究也证实卵巢癌发生发展及其耐药受表观遗传学的调控，如DNA甲基化、组蛋白修饰、MicroRNA等调控相关基因，而通过调控表观遗传学如DNA甲基转移酶抑制剂或组蛋白去乙酰化酶抑制剂的作用能够显著提高卵巢癌的疗效，因此研究表观遗传学与卵巢癌的耐药机制有望为临床治疗卵巢癌提供新的思路与研究基础。

关键词: 卵巢癌, 耐药, 表观遗传学

Abstract: Ovarian cancer is one of the most common malignant tumors of the three cancers female genital organs, and its mortality rate ranks first in gynecological malignancies. The research shows that the occurrence and development of tumor resistance is related to epigenetics. The related research also confirmed that epigenetics regulated the occurrence and development of ovarian cancer and drug resistance, such as DNA methylation, histone modification and MicroRNA genes. The epigenetics such as DNA methyltransferase inhibitors or histone deacetylase inhibitors can significantly improve the curative effect of ovarian cancer. The study of epigenetics and drug resistance in ovarian cancer are expected to provide new ideas and basis for clinical treatment of ovarian cancer.

Key words: Ovarian cancer, drug resistance, epigenetic