关键词: 卵巢肿瘤, 自噬, 1-磷脂酰肌醇3-激酶, Beclin1, LC3

Abstract: Ovarian cancer is the most lethal gynecological malignancy tumor, its early diagnosis is difficult. In spite of the progression in surgery and chemotherapy, the mortality of ovarian cancer almost remains the same. Autophagy, type II programmed cell death, has came into attention with the development of researches. The role of autophagy in ovarian cancer is bidirectional, it can not only inhibit the occurrence of tumor, but also protect tumor cells and promote tumor metastasis. Some related factors of autophagy play an important role in the development of ovarian cancer, they are also closely related to the prognosis of ovarian cancer. The discovery of the mechanism of autophagy related factors in ovarian cancer provides new ideas and targets for the treatment of ovarian cancer.

Key words: Ovarian neoplasms, Autophagy, 1-phosphatidylinositol 3-kinase, Beclin1, LC3