国际妇产科学杂志

国际妇产科学杂志 ›› 2018, Vol. 45 ›› Issue (4): 450-454.

• 综述 • 上一篇    下一篇

子宫内膜样腺癌MELF浸润模式的研究进展

韩虹宇，姜继勇   

  1. 116033  大连医科大学附属大连市妇产医院暨大连市妇幼保健院
  • 收稿日期:2018-03-21 修回日期:2018-06-01 出版日期:2018-08-15 发布日期:2018-08-15

Research Progress of the Microcystic, Elongated, and Fragmented Pattern of Invasion in Endometrial Carcinoma

HAN Hong-yu，JIANG Ji-yong   

  1. Dalian Obstetrics and Gynecology Hospital Affiliated to Dalian Medical University，Dalian City Maternity Hospital，Dalian 116033，Liaoning Province，China
  • Received:2018-03-21 Revised:2018-06-01 Published:2018-08-15 Online:2018-08-15

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摘要： 子宫内膜癌是女性生殖系统常见的恶性肿瘤之一，其最常见的病理形态为子宫内膜样腺癌。早期子宫内膜癌预后较好，但仍有少部分患者预后不良。影响子宫内膜癌预后的不良因素包括肿瘤组织学分级、子宫肌层侵犯深度、淋巴脉管间隙浸润（lymphovascular space invasion，LVSI）、宫颈间质受累及淋巴结转移等。伴微囊性、伸长及碎片状（microcystic，elongated，fragmented，MELF）浸润是子宫内膜样腺癌的一种特殊的浸润子宫肌层的方式。多项研究证实MELF浸润模式与某些影响预后的不良病理因素相关，但是MELF浸润模式的预后意义尚不明确。现就MELF浸润模式的临床病理特征以及预后意义的研究进展进行综述，以期为未来MELF浸润模式的相关研究提供理论参考。

关键词: 子宫内膜肿瘤, 肿瘤侵润, MELF浸润模式, 预后

Abstract: Endometrial cancer is one of the common malignant tumors of the female reproductive system. The most common pathological form of endometrial cancer is endometrial endometrioid adenocarcinoma. The prognosis of early endometrial cancer is better, but there are still a few patients with poor prognosis. Factors that affect the prognosis of endometrial cancer include histological grade, depth of myometrial invasion, lymphovascular space invasion (LVSI), cervical stroma involvement, and lymph node metastasis. Microcystic, elongated and fragmented (MELF) pattern is a special myometrial invasion pattern of endometrial endometrioid adenocarcinoma. Several studies have confirmed that the MELF pattern is associated with some adverse pathological factors that affect the prognosis, but the prognostic significance of MELF pattern remains unclear. Clinicopathological features and prognostic significance of MELF pattern are now discussed in this review in order to provide a theoretical reference for the related research of MELF pattern in the future.

Key words: Endometrial neoplasms, Neoplasm invasiveness, Microcystic, elongated, fragmented pattern of invasion, Prognosis

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