国际妇产科学杂志

国际妇产科学杂志 ›› 2019, Vol. 46 ›› Issue (2): 224-228.

• 综述 • 上一篇    下一篇

铁过载与子宫内膜异位症病程进展的相关性

刘梦娜，许天敏，张琨   

  1. 130041 长春，吉林大学第二医院检验科（刘梦娜），妇产科（许天敏），研究中心（张琨）
  • 收稿日期:2018-12-14 修回日期:2019-01-30 出版日期:2019-04-15 发布日期:2019-04-15
  • 通讯作者: 张琨，E-mail：zk303@jlu.edu.cn E-mail:zk303@jlu.edu.cn
  • 基金资助:
    吉林省科技发展计划项目（20160307025YY）

Iron-Overload and Its Relation with the Development of Endometriosis

LIU Meng-na, XU Tian-min, ZHANG Kun   

  1. Department of Clinical Laboratory（LIU Meng-na）, Department of Obstetrics and Gynecology （XU Tian-min）, Department of Research Center（ZHANG Kun）, The Second Hospital of Jilin University, Changchun 130041, China
  • Received:2018-12-14 Revised:2019-01-30 Published:2019-04-15 Online:2019-04-15
  • Contact: ＺHANG Kun, E-maｉｌ：zk303@jlu.edu.cn E-mail:zk303@jlu.edu.cn

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摘要： 子宫内膜异位症（endometriosis，EMs）是一种常见的妇科良性疾病，在育龄妇女发病率为10%～15%，近年来有明显升高的趋势。EMs虽为良性疾病，却具有浸润、转移等恶性生长行为，且存在一定的恶变率，导致EMs患者患上皮性卵巢癌的风险显著增高。近年来围绕EMs盆腔微环境的研究发现，铁过载在EMs的发生、发展中起重要作用。经血逆流或异位病灶溶血产生过量的铁引起铁过载，不仅破坏异位囊肿或腹腔的氧化还原平衡导致氧化应激损伤，而且影响巨噬细胞清除功能，还激活核因子κB（NF-κB）信号通路介导炎症反应。此外，活性铁在与雌激素不断平衡调节过程中也导致了EMs向恶性转变。现就EMs发病时铁过载的形成过程及通过不同方式参与EMs的病程进展进行综述。

关键词: 铁超负荷, 子宫内膜异位症, 炎症, 氧化应激

Abstract: Endometriosis(EMs) is a common gynecologic disorder with an estimated incidence of 10%-15% among women of reproductive age. While in itself a benign lesion, EMs shares several characteristics with invasive cancer and has been shown to undergo malignant transformation. It has been associated with an increased risk of epithelial ovarian carcinoma (EOC). Recent research focused on pelvic microenvironment found that iron overload plays an important role in the initiation and development of EMs. Higher levels of iron, which is probably released after lysis of erythrocytes or retrograde menstruation, has been found in the peritoneal fluid of patients with EMs. Free iron, which is a strong prooxidant, not only disturbs the balance of redox reaction causing oxidative stress damage, but also verwhelms peritoneal protection of macrophage. Iron overload is also implicated in activation of NF-κB signaling pathway, giving rise to the production of numerous inflammatory factors. Moreover, iron metabolism may interact with and modulate estrogen, involved in the malignant transition of EMs. Here we summarizes the most recent studies concerning with iron overload and its relation with the initiation and development of EMs.

Key words: Iron overload, Endometriosis, Inflammation, Oxidative stress