国际妇产科学杂志

国际妇产科学杂志 ›› 2019, Vol. 46 ›› Issue (4): 370-373.

• 综述 • 上一篇    下一篇

子宫内膜异位症相关信号通路研究进展

朱小琳，韩亚光，韩延华，胥风华，丛晶，王雪莲   

  1. 150001 哈尔滨，黑龙江中医药大学附属第二医院（朱小琳）；黑龙江中医药大学附属第一医院（韩亚光，韩延华，胥风华，丛晶，王雪莲）
  • 收稿日期:2018-12-28 修回日期:2019-04-09 出版日期:2019-08-15 发布日期:2019-08-15
  • 通讯作者: 韩亚光，E-mail：13945053676@126.com E-mail:13945053676@126.com
  • 基金资助:
    2018年度普通本科高校青年创新人才（UNPYSCT-2018229）

Advances in Research on Signaling Pathway Related to Endometriosis

ZHU Xiao-lin，HAN Ya-guang，HAN Yan-hua，XU Feng-hua，CONG Jing，WANG Xue-lian   

  1. The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150001，China（ZHU Xiao-lin）; The First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150040，China（HAN Ya-guang，HAN Yan-hua，XU Feng-hua，CONG Jing，WANG Xue-lian）
  • Received:2018-12-28 Revised:2019-04-09 Published:2019-08-15 Online:2019-08-15
  • Contact: HAN Ya-guang，E-mail：13945053676@126.com E-mail:13945053676@126.com

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摘要： 子宫内膜异位症（EMs）作为妇科公认的疑难病，严重影响女性身心健康，因其病变多态性、侵袭性、广泛性，其发病机制目前尚无统一定论。相关信号通路的异常激活、多细胞因子的共同作用均会导致异位内膜细胞黏附、侵袭以及炎症的形成，目前丝裂原活化蛋白激酶（MAPKs）、Wnt/β-连环蛋白（β-catenin）、转化生长因子β（TGF-β）/Smad、核因子κB（NF-κB）、Ras同源基因/Rho相关螺旋卷曲蛋白激酶（Rho/ROCK）、Janus激酶2/转录活化因子3（JAK2/STAT3）等信号通路与EMs的发生、发展密切相关。现从以上6条通路阐述EMs的发病机制，为其寻找有效靶向药物治疗提供新的思路。

关键词: 子宫内膜异位症, 子宫内膜, 信号传导, 病理过程, 综述

Abstract: Endometriosis (EMs), as a difficult disease recognized by gynecologists, has seriously affected the physical and mental health of women. Because of its polymorphism, invasion and extensiveness, there is no uniform conclusion on the pathogenesis of EMs. Abnormal activation of related signaling pathways and the interaction of multiple cytokines can lead to the formation of ectopic endometrium adhesion, invasion and inflammation. At present，mitogen-activated protein kinases (MAPKs) pathway, Wnt/β-catenin pathway, transforming growth factor β (TGF-β)/Smad pathway, nuclear factor κB (NF-κB) pathway, Ras homolog gene/ Rho-associated coiled coil-forming protein kinase (Rho/ROCK) pathway, Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway are closely related to the pathogenesis of EMs. This review aims to illustrate the pathogenesis of EMs by explaining these mentioned pathways，to provide a new strategy for finding effective drugs to treat EMs.

Key words: Endometriosis, Endometrium, Signal transduction, Pathologic processes, Review