关键词: 长链非编码RNA, 卵巢肿瘤, 癌, 综述

Abstract: Ovarian cancer is the second most common malignant tumor in the female reproductive system. Its development involves a variety of genetic and environmental factors. Its low survival rate and easy recurrence have become the focus and difficulty of research. The genome project has shown in recent years that less than 2% of the nucleic acid sequences in the genome sequence can be used to encode proteins, and the remaining 98% of the sequences do not encode any proteins. These gene sequences were once considered "non-functional sequences", but recent studies have shown that these non-functional sequences contain a wealth of information and functions. Most of these non-functional sequences are long non-coding RNAs (lncRNAs) with more than 200 bases. LncRNAs are a group of endogenous cellular RNAs encoded by the mammalian genome that are more than 200 bp in length. Many researchers at home and abroad have discovered a few lncRNAs related to malignant tumors, and they believe that lncRNAs may play a role in regulating tumorigenesis and invasion. This article summarizes the research progress of lncRNA in ovarian cancer.

Key words: long non-coding RNA, Ovarian neoplasms, Carcinoma, Review