核因子κB在子宫内膜异位症发病中的作用

doi:10.12280/gjfckx.20220257

摘要/Abstract

摘要：

子宫内膜异位症（endometriosis,EMs）是妇科常见及多发病,发病机制尚未完全清楚,已证实其与炎症反应、免疫因素、内分泌及激素等关系密切。核因子κB（nuclear factor-κB,NF-κB）是一种蛋白复合物,在DNA转录、细胞因子合成、细胞凋亡与分化等方面发挥重要作用。异位、在位和正常子宫内膜细胞上NF-κB的表达具有差异性,同时NF-κB在炎症反应、激素合成、黏附因子及血管生成因子等方面发挥重要的作用,而这些方面与EMs的发生、发展关系密切。综述NF-κB在EMs发病中可能的作用,以期为治疗EMs提供新的思路和方法。

关键词: NF-κB, 子宫内膜异位症, 细胞因子类, 炎症, 雌激素类, 孕激素类, 细胞黏附, 血管内皮生长因子类

Abstract:

Endometriosis (EMs) is a common and frequently-occurring disease in gynecology. The pathogenesis of EMs is not fully understood, but it has been proved to be closely related to inflammatory responses, immune factors, endocrine and hormonal factors. Nuclear factor-κB (NF-κB) is a protein complex that plays an important role in DNA transcription, cytokine synthesis, apoptosis and differentiation. NF-κB expression is different in ectopic, in eutopic and normal endometrial cells. NF-κB plays an important role in inflammatory response, hormone synthesis, adhesion factor and angiogenesis factor, which are closely related to the occurrence and development of EMs. The possible role of NF-κB in the pathogenesis of EMs is reviewed in order to provide new ideas and methods for the treatment of EMs.

Key words: NF-kappa B, Endometriosis, Cytokines, Inflammation, Estrogens, Progestins, Cell adhesion, Vascular endothelial growth factors

王嵩, 张崴, 宋殿荣. 核因子κB在子宫内膜异位症发病中的作用[J]. 国际妇产科学杂志, 2022, 49(4): 461-465.

WANG Song, ZHANG Wei, SONG Dian-rong. The Role of NF-κB in the Pathogenesis of Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 461-465.

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