子宫内膜微生物群的组成及研究进展

doi:10.12280/gjfckx.20240451

摘要/Abstract

摘要：

近年来，子宫内膜微生物群的研究逐渐受到重视，不同比例的菌群组成与生殖系统疾病及病理性妊娠的发生密切相关。子宫内膜微生物群的组成尚未完全明确，许多研究秉持子宫内膜中以乳杆菌为主导微生物的观点，但因各个研究标本采集及分析方法的不同，对该理论仍存在争议。16S rRNA测序技术是目前子宫内膜微生物群最常用的研究方法，同时亦有利用不同组学技术的研究报道。子宫内膜容受性是胚胎成功植入的关键，子宫内膜中乳杆菌的优势可能与生殖预后改善有关。慢性子宫内膜炎（chronic endometritis，CE）已被证实与不孕、复发性流产及反复种植失败有关。目前尚未证实子宫内膜微生物失衡与CE的相关性，但有研究发现CE患者的乳杆菌比例下降，提示子宫内膜微生物与CE可能具有一定相关性。本文综述子宫内膜微生物组成的不同研究结果及研究方法，并总结近年子宫内膜微生物对于子宫内膜容受性及CE的影响及作用。

关键词: 微生物群, 子宫内膜, 子宫内膜微生物群, 子宫内膜容受性, 慢性子宫内膜炎

Abstract:

In recent years, the research of endometrial microbiota has gradually gained attention. The composition of microbial communities in different proportions is closely related to the occurrence of reproductive system disease and pathological pregnancies. The composition of endometrial microbiota has not yet been fully elucidated. Many studies hold the view that lactobacilli dominate the endometrial microbiome, but this theory remains controversial due to differences in sample collection and analysis methods across studies. The 16S rRNA sequencing technology is currently the most commonly used method for studying the endometrial microbiota, although studies using different omics technologies have also been reported. Endometrial receptivity is crucial for successful embryo implantation, and the dominance of lactobacilli in the endometrium may be associated with improved reproductive outcomes. Chronic endometritis (CE) has been confirmed to be associated with infertility, recurrent miscarriage, and repeated implantation failure. Although the correlation between endometrial microbial imbalance and CE has not yet been established, some studies have found that a decrease in the proportion of lactobacilli in CE patients, suggesting a potential association between the endometrial microbiome and CE. This paper reviews the different research findings and methods on the composition of endometrial microbiome and summarizes the recent impacts and roles of endometrial microbiota on endometrial receptivity and CE.

Key words: Microbiota, Endometrium, Endometrial microbiota, Endometrial receptivity, Chronic endometritis

钟晓盈, 刘海元. 子宫内膜微生物群的组成及研究进展[J]. 国际妇产科学杂志, 2024, 51(5): 481-485.

ZHONG Xiao-ying, LIU Hai-yuan. Composition and Research Progress of the Endometrial Microbiota[J]. Journal of International Obstetrics and Gynecology, 2024, 51(5): 481-485.

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