Delta样配体4在妇科恶性肿瘤中的研究进展

doi:10.12280/gjfckx.20250776

摘要/Abstract

摘要：

宫颈癌、卵巢癌和子宫内膜癌是导致女性死亡的重要病因，虽然规范治疗可使部分患者病情得到改善，但仍有相当比例的患者预后不佳，病情持续进展。早期诊断和治疗是改善妇科恶性肿瘤患者预后、减轻疾病负担的关键策略，因此探索更有效的治疗靶点具有重要意义。Delta样配体4（Delta-like ligand 4，DLL4）作为Notch信号通路的关键配体，在肿瘤血管生成、肿瘤干细胞维持和免疫环境调控中发挥重要作用。近年研究发现，DLL4在卵巢癌、宫颈癌和子宫内膜癌等多种妇科恶性肿瘤中显著高表达，且其表达水平与肿瘤分期、转移和不良预后密切相关，显示出作为新型靶向治疗靶点的潜力。系统阐述DLL4的生物学功能，并就DLL4与三大妇科恶性肿瘤的相关性研究进展进行综述，以期为妇科恶性肿瘤的精准治疗提供新思路。

关键词: 受体，Notch, 生殖器肿瘤，女（雌）性, 血管生成抑制剂, 抗肿瘤联合化疗方案, Delta样配体4

Abstract:

Cervical cancer, ovarian cancer and endometrial cancer are important causes of female mortality. Although standardized treatment can improve the condition of some patients, a considerable proportion of patients still have a poor prognosis and continuous disease progression. Early diagnosis and treatment are key strategies to improve the prognosis of patients with gynecological malignancies and reduce the disease burden. Therefore, exploring more effective therapeutic targets is of great significance. Delta-like ligand 4 (DLL4), as a key ligand of the Notch signaling pathway, plays an important role in tumor angiogenesis, tumor stem cell maintenance, and immune environment regulation. In recent years, studies have found that DLL4 is significantly highly expressed in various gynecological malignancies such as ovarian cancer, cervical cancer and endometrial cancer, and its expression level is closely related to tumor stage, metastasis and poor prognosis, showing the potential as a novel targeted therapeutic target. This article systematically elaborates on the biological functions of DLL4 and reviews the research progress on the correlation between DLL4 and the three major gynecological malignancies, aiming to provide new ideas for the precise treatment of gynecological malignancies.

Key words: Receptors, Notch, Genital neoplasms, female, Angiogenesis inhibitors, Antineoplastic combined chemotherapy protocols, Delta-like ligand 4

白耀俊, 王思瑶, 李红丽, 刘畅. Delta样配体4在妇科恶性肿瘤中的研究进展[J]. 国际妇产科学杂志, 2025, 52(6): 680-684.

BAI Yao-jun, WANG Si-yao, LI Hong-li, LIU Chang. Research Progress on Delta-Like Ligand 4 in Gynecological Malignancies[J]. Journal of International Obstetrics and Gynecology, 2025, 52(6): 680-684.

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