国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (4): 462-465.

• 综述 • 上一篇    下一篇

骨形态蛋白4和骨形态蛋白7与多囊卵巢综合征

黄晓，金洁雯，王勇   

  1. 210093 南京大学医学院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-08-15 发布日期:2014-08-15
  • 通讯作者: 王勇

Bone Morphogenetic Protein 4，Bone Morphogenetic Protein 7 and Polycystic Ovary Syndrome

HUANG Xiao，JIN Jie-wen，WANG Yong   

  1. Medical School of Nanjing University，Nanjing 210093，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-08-15 Online:2014-08-15
  • Contact: WANG Yong

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摘要： 多囊卵巢综合征（PCOS）是育龄妇女最常见的生殖内分泌紊乱疾病之一。以稀发排卵或不排卵、高雄激素血症以及形态学上的多囊卵巢为主要表现特征。迄今为止，其病因和病理机制尚不清楚。有研究显示，PCOS的形成与卵源性的某些转录因子有关，如转化生长因子β（TGF-β）。骨形态蛋白4（BMP4）和BMP7是TGF-β超家族的重要成员，在卵泡的形成、排卵、颗粒细胞的生长成熟和凋亡中发挥重要作用。因此了解BMP4和BMP7在女性生殖系统的调节作用，对研究PCOS的病因机制以及治疗有重要价值。

关键词: 多囊卵巢综合征, 骨形态发生蛋白质类, 骨形态发生蛋白受体

Abstract: Polycystic ovary syndrome（PCOS） is one of the common endocrine disorder affecting women of reproductive age，and is characterized by oligo- or anovulation，hyperandrogenism and polycystic ovaries. Some findings show that the cause of PCOS has something to do with the abnormal regulation of transcription factors，such as the Transforming Growth Factor-beta（TGF-β） superfamily. Bone Morphogenetic Protein 4（BMP4） and Bone Morphogenetic Protein 7（BMP7） are both important members in TGF-β superfamily， and play an significant role in the folliculogenesis、ovulation and the development and apotosis of granulosa cells in ovary. As a result，in order to know more about the pathogenesis and treatment of PCOS， it is necessary to make clear the regulation function of BMP4 and BMP7 in female reproductive system.

Key words: Polycystic ovary syndrome, Bone morphogenetic proteins, Bone morphogenetic protein receptors