国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (1): 64-67.

• 综述 • 上一篇    下一篇

神经生长因子及其受体在卵巢癌中的作用

许 嵩 仝进毅   

  1. 310006 杭州市第一人民医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-02-15 发布日期:2011-02-15

The Effect of Nerve Growth Factor and Its Receptor in Ovarian Cancer

XU Song, TONG Jin-yi   

  1. Hangzhou First People’s Hospital, Hangzhou 310006, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-02-15 Online:2011-02-15

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摘要： 神经生长因子（nerve growth factor，NGF）是神经营养因子家族的一种多肽激素，除能促进神经纤维的生长外，还可以通过自分泌和旁分泌的方式作用于某些特定类型的肿瘤组织，影响其发生、发展和转移。在卵巢癌中，NGF通过与其受体TrkA和p75 NTR结合而促进肿瘤供给血管的生成，影响细胞因子的水平，在卵巢癌的发生、发展、侵袭和转移中发挥着不可忽略的作用。充分认识NGF的作用机制，将为其在肿瘤早期诊断、治疗及判定预后方面开辟新领域。

关键词: 卵巢肿瘤, 神经生长因子, 受体, trkA, 受体, 神经生长因子类, 血管内皮生长因子类

Abstract: Nerve growth factor（NGF）is a poly-peptide hormone of neurotrophin family. It can stimulate the growth of nerve fibers, besides, it also has the impact on certain kinds of tumor by autocrine and paracrine secretion, and result in the modulation of tumor generation, development and metastasis. Regarding the ovarian cancer, after bind to its receptor TrkA and p75, NGF can enhance the formation of cancer’s supplemental vessels, influence the level of cytokine, thereby it will play an important role in the development, invasion and metastasis of ovarian tumor. When we recognize the mechanism of NGF, it will open a new vision on ovarian tumor of early diagnosis, treatment and prognosis.

Key words: Ovarian neoplasms, Nerve growth factor, Receptor, trkA, Receptors, nerve growth factor