国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (1): 60-63.

• 综述 • 上一篇    下一篇

卵巢肿瘤干细胞耐药机制研究进展

吴开元 史惠蓉   

  1. 450052 郑州大学第一附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-02-15 发布日期:2011-02-15

Research Progress in Determing the Relationship Between Ovarian Cancer Stem Cells and Chemoresistance

WU Kai-yuan, SHI Hui-rong   

  1. Department of Gynecology and Obstetrics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-02-15 Online:2011-02-15

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摘要： 卵巢癌治疗中的主要问题是高复发率和产生耐药性。肿瘤干细胞具有无限增殖的能力，对药物的耐受性增加，提示肿瘤干细胞与化疗耐药的关系密切。从耐药卵巢癌细胞中可分选出具有特定表面标志的肿瘤干细胞，其为肿瘤形成提供可自我更新并在传代中保持肿瘤特性不变，是卵巢癌耐药性产生和复发的根本原因。利用卵巢癌干细胞表面标志分子的特异性，使化疗药物选择性地与卵巢癌干细胞结合，彻底消除肿瘤复发和耐药根源，可为卵巢癌患者提供更有效的化疗方案。

关键词: 卵巢肿瘤, 肿瘤干细胞, 抗药性, 肿瘤, 生物学标记, 免疫, 多药耐药相关蛋白质类

Abstract: A major problem in the treatment of ovarian cancer is the high percentage of recurrence and chemoresistance. Cancer stem cells（CSCs） can proliferate indefinitely, be proved enhancing chemoresistance and indicate a close relationship with chemoresistance. CSCs with definite cell surface maker can be separated from chemoresistant ovarian cancer cells, they can provide a reservoir of cells that can self-renew, maintain the tumor which make up the bulk of the tumor and may be the primary source of recurrence and chemoresistance. According to the special cell-surface marker and making chemotherapeutics selectively binding with ovarian cancer stem cells, can eliminate cancer recurrence and chemoresistance thoroughly and provide more effective chemotherapy shedules.

Key words: Ovarian neoplasms, Neoplastic stem cells, Drug resistance, neoplasm, Biological markers, Immunity