国际妇产科学杂志

国际妇产科学杂志 ›› 2016, Vol. 43 ›› Issue (5): 524-527.

• 综述 • 上一篇    下一篇

宫颈上皮内瘤变分子生物学指标的研究进展

宋妮娜，瞿全新   

  1. 300192 天津医科大学一中心临床学院（宋妮娜，瞿全新）；天津市黄河医院（宋妮娜）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-10-15 发布日期:2016-10-15

Research Advances in Molecular Biological Indicators of Cervical Intraepithelial Neoplasia

SONG Ni-na，QU Quan-xin   

  1. Center of Clinical College，Medical University of Tianjin，Tianjin 300192，China（SONG Ni-na，QU Quan-xin）；Tianjin Huanghe Hospital，Tianjin 300110，China（SONG Ni-na）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-10-15 Online:2016-10-15

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5393

被引次数

3

摘要： 宫颈癌是妇科最常见的恶性肿瘤之一，近年来宫颈癌的发病率逐年上升，且有年轻化趋势。宫颈上皮内瘤变（CIN）是由高危型人乳头瘤病毒（HPV）的持续性感染引起的，是宫颈癌的癌前病变，其反映宫颈癌发生发展中的连续过程，从CIN发展为宫颈癌需要较长的时间。在CIN的进展过程中，许多基因结构和功能都会发生变化。近年来的研究发现，在CIN和宫颈癌的组织中存在着一些表达异常的生物学标记物，这些生物学标记物与前驱病变级别和肿瘤是否发生转移相关，将这些基因作为CIN进展的分子生物学标志物进行检测，早期发现和诊断宫颈癌已成为目前研究的热点。综述CIN研究的前沿性分子生物学指标。

关键词: 宫颈上皮内瘤样病变, 宫颈肿瘤, 生物学标记, 端粒，末端转移酶, 白细胞介素类, Toll样受体

Abstract: Cervical cancer is one of the most common gynecological malignant tumors. In recent years, the incidence of cervical cancer has increased year by year, and there is a trend of youth. Cervical intraepithelial neoplasia (CIN) is caused by persistent infection of high risk human papillomavirus (HPV). It is a precancerous lesion of cervical cancer, and it reflects the continuous process of the development of cervical cancer. From the development of CIN to cervical cancer needs a long time. In the progress of CIN, many gene structure and function will change. Recent studies have found that there are some abnormal expression of biological markers between the CIN and cervical cancer tissue, which are related to the level of the precursor and the metastasis of the tumor. These genes as CIN progression of molecular biomarkers for testing to early detect and diagnosis of cervical cancer has become a hot research. In this article, we reviewed the research on the frontier molecular biology of CIN.

Key words: Cervical intraepithelial neoplasia, Uterine cervical neoplasms, Biological markers, Telomerase, Interleukins, Toll-like receptors