国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (6): 651-653.

• 论著 • 上一篇    下一篇

Vaspin基因多态性与多囊卵巢综合征的相关性

柴义青，刘洁   

  1. 300100 天津市中心妇产科医院超声中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-12-15 发布日期:2015-12-15
  • 通讯作者: 刘洁

Correlation between Vaspin Gene Polymorphism and Polycystic Ovary Syndrome

CHAI Yi-qing，LIU Jie   

  1. Ultrasonic Center，Tianjin Central Hospital of Gynecology Obstetrics，Tianjin 300100，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-12-15 Online:2015-12-15
  • Contact: LIU Jie

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摘要： 目的：研究Vaspin基因多态性与多囊卵巢综合征（PCOS）的关系。方法：选择2011年7月—2014年8月天津市中心妇产科医院确诊的PCOS患者200例为PCOS组，对照组选取非PCOS且无糖代谢异常的200例正常体检者。观察2组Vaspin rs2236242位点基因多态性基因频率的差别。 结果：2组Vaspin rs2236242位点A等位基因与T等位基因频率比较，差异有统计学意义（OR=0.68，95%CI：0.51～0.91，P=0.009）。共显性遗传模型分析显示，TA基因型（OR=0.51，95%CI：0.33~0.79，P=0.002）和AA基因型者（OR=0.47，95%CI：0.23～0.95，P=0.035）的PCOS发病风险低于TT基因型者。显性遗传模型分析显示，TA+AA基因型者PCOS发病风险低于TT基因型者（OR=0.50，95%CI：0.33～0.77，P=0.001）。隐性遗传模型分析显示，AA基因型与TT+TA基因型者PCOS发病风险相似（OR=0.71，95%CI：0.37～1.38，P=0.317）。结论：Vaspin rs2236242位点基因多态性与PCOS发病有关，等位基因A及AA、TA基因型对PCOS发病可能起抑制作用。

关键词: 多囊卵巢综合征, 丝氨酸蛋白酶抑制剂, 多态现象, 遗传, 不育

Abstract: Objective：To investigate the association between polycysitic ovary syndrome（PCOS） and gene polymorphism of Vaspin. Methods：This case-control study was performed on 200 patients with PCOS（PCOS group） and 200 healthy women（control group） from July 2011 to Augest 2014 diagnosed at Tianjin Central Hospital of Gynecology Obstetrics. The polymorphism of Vaspin rs2236242 were compared between two groups. Results：A significant difference against PCOS was found for Vaspin rs2236242 frequency in A vs. T allele（OR=0.68，95%CI：0.51-0.91，P=0.009）. The incidence of PCOS was lower in TA（OR=0.51，95%CI：0.33-0.79，P=0.002） or AA genotype （OR=0.47，95%CI：0.23-0.95，P=0.035）than in TT genotype in our Codominant and Dominant models. Dominant genetic model analysis showed that the incidence of PCOS was lower in TA+AA genotype than in TT genotype（OR=0.50，95%CI：0.33-0.77，P=0.001）. There were no significant differences in genotype frequencies between case and control group in recessive models（OR=0.71，95%CI：0.37-1.38，P=0.317）. Conclusions：The results showed that the polymorphism of Vaspin gene are associated with risk for PCOS. A allele and AA, TA genotype may play a role in the inhibition of PCOS disease.

Key words: Polycystic ovary syndrome, Serine proteinase inhibitors, Polymorphism, genetic, Infertility