国际妇产科学杂志

国际妇产科学杂志 ›› 2016, Vol. 43 ›› Issue (1): 8-10.

• 综述 • 上一篇    下一篇

基质金属蛋白酶降解胞外基质致未足月胎膜早破研究进展

李雯，常颖，李星，徐亚玲，陈叙   

  1. 300100 天津市中心妇产科医院（李雯，常颖，陈叙）；天津医科大学（李星，徐亚玲，）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-02-15 发布日期:2016-02-15

Research Progress of Matrix Metalloproteinases in Preterm Premature Rupture of Membranes through Degrading Extracellular Matrix

LI Wen, CHANG Ying, LI Xing, XU Ya-ling, CHEN Xu   

  1. Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, China（LI Wen，CHANG Ying，CHEN Xu）；Tianjin Medical University，Tianjin 300070，China（LI Xing，XU Ya-ling）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-02-15 Online:2016-02-15

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摘要： 早产是威胁围生儿生命健康的首要病因。据统计，2012年中国早产发生率为8.1%。未足月胎膜早破（preterm premature rupture of membranes，PPROM）占早产的25%～30%，重要诱因为宫内感染。近年研究发现，PPROM的分子机制为胎膜组织中胞外基质过早降解，主要由基质金属蛋白酶（matrix metalloproteinases，MMPs）在胎膜组织中的激活引起。MMPs的激活原因有炎症因子的表达增高，如白细胞介素1（IL-1），IL-6以及肿瘤坏死因子α（TNF-α），但具体机制尚有待研究。MMPs在正常分娩与PPROM发生过程中的激活、分泌及其影响因素仍需探索，其可能作为预测妊娠结局的标记物，为PPROM的预防与治疗提供突破点。

关键词: 基质金属蛋白酶类, 感染, 细胞因子类, 早产, 胎膜早破

Abstract: Preterm birth is the first critical factor of life, threatening diseases for the perinatal. According to the statistics, the preterm birth rate in China reached 8.1% in 2012. And the frequency of preterm premature rupture of membranes（PPROM） is about 25%-30%, and intrauterine infection is the principal element. The recent research shows that a molecular mechanism of PPROM is advanced degradation of extracellular matrix, which due to the activation of matrix metalloproteinases（MMPs） in fetal membrane. The high expression of cytokines, such as IL-1, IL-6 and TNF-α, maybe the reason of MMPs′ activation. The process of activation and secretion of MMPs in term labor and preterm birth still need to be explored, which may be considered as a marker of pregnancy outcome. MMPs can provide a breakpoint of prevention and therapy for PPROM.

Key words: Matrix metalloproteinases, Infection, Cytokines, Premature birth, Fetal membranes, premature rupture