国际妇产科学杂志 ›› 2018, Vol. 45 ›› Issue (5): 541-543.

• 综述 • 上一篇    下一篇

COX-2、E-cadherin和PPAR-γ与子痫前期的研究进展

张娜娜,王晨虹   

  1. 518100  深圳,南方医科大学深圳医院妇产科
  • 收稿日期:2018-04-27 修回日期:2018-06-05 出版日期:2018-10-15 发布日期:2018-10-18
  • 通讯作者: 王晨虹,E-mail:szwangchenhong@vip.163.com E-mail:szwangchenhong@vip.163.com
  • 作者简介:2018-07-31

Research Progress of COX-2, E-cadherin and PPAR-γ in Pre-eclampsia

ZHANG Na-na, WANG Chen-hong   

  1. Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University, Shenzhen 518100, Guangdong Province, China
  • Received:2018-04-27 Revised:2018-06-05 Published:2018-10-15 Online:2018-10-18
  • Contact: WANG Chen-hong,E-mail:szwangchenhong@vip.163.com E-mail:szwangchenhong@vip.163.com

摘要: 子痫前期(PE)是妊娠时期特有的疾病,严重影响孕产妇和围生儿的生命健康安全,其发病机制尚不完全明确。环氧合酶2(COX-2)是炎症反应中重要的可诱导同工酶,其产物前列腺素是重要的炎症介质;E-钙黏蛋白(E-cadherin)可促进细胞之间的相互作用,是一个潜在的识别细胞滋养层细胞的标志性蛋白;过氧化物酶体增殖物激活受体γ(PPAR-γ)经配体激活后,参与各种生理病理过程。此外,COX-2分别与E-cadherin和PPAR-γ在某些疾病的发生、发展中具有一定的相关性。COX-2、E-cadherin和PPAR-γ与PE的发病也密切相关,对3个因子的深入研究能为PE的发病机制提供更多线索,从而为PE的预测、预防和治疗提供新的方向和思路。

关键词: 先兆子痫, 前列腺素内过氧化物合酶类, 钙黏着糖蛋白类, PPAR-γ

Abstract: Pre-eclampsia (PE) is a specific disease of pregnancy, which seriously affects the health and safety of pregnant women and perinatal infants. The pathogenesis of PE is not yet clear. Cyclooxygenase-2(COX-2) is an important inducible isoenzyme in the inflammatory response. Its prostaglandin is an important inflammatory mediator. E-cadherin has the function of promoting mutual among cells,and it is a potential marker for identifying cell trophoblast cells. Peroxisome proliferator-activated receptor-γ(PPAR-γ) is involved in various physiological and pathological processes after ligand activation. In addition, COX-2 is associated with E-cadherin and PPAR-γ in the development of certain diseases, respectively. COX-2, E-cadherin and PPAR-γ are closely related to the onset of PE. The in-depth study of three factors can provide more clues for the pathogenesis of PE, thus providing new directions and ideas for the prediction, prevention and treatment of the disease.

Key words: Pre-eclampsia, Prostaglandin-endoperoxide synthases, Cadherins, PPAR gamma