关键词: 铁死亡, 卵巢肿瘤, 活性氧, 基因, p53, 微RNAs

Abstract: Ovarian cancer, as a kind of female reproductive system tumor with extremely high malignant degree, is the leading cause of death in gynecologic malignancies. Ovarian cancer is insidious and lacks specific detection methods at the early stage. It often develops into recurrent and multi-drug resistant diseases in the middle and late stages, with poor prognosis. In recent years, relevant basic and clinical studies have found that ferroptosis plays an important role in the development of ovarian cancer. Many scholars believe that iron death, as an iron-dependent cell death mode, is closely related to a variety of biochemical processes and can inhibit the proliferation of tumor tissues by depriving iron in cancer cells or changing the metabolism of iron ions in tumor tissues. Moreover, iron death was also identified as a potential therapeutic target for ovarian cancer. This paper summarizes the biochemical process of iron death and its research progress in ovarian cancer, and provides new ideas for the treatment of ovarian cancer.

Key words: Ferroptosis, Ovarian neoplasms, Reactive oxygen species, Genes, p53, MicroRNAs