国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (5): 322-324.

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肿瘤抑制基因DNA甲基化与宫颈癌研究进展

刘 洋, 胡 越, 凌志强   

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  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-10-15 发布日期:2010-10-15

Progression of Tumor-suppressing Gene Methylation in Cervical Cancer

LIU Yang, HU Yue, LING Zhi-qiang   

  1. Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China（LIU Yang，HU Yue）; Zhejiang Tumor Research Institution, Hangzhou 310022, China（LING Zhi-qiang）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-10-15 Online:2010-10-15

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摘要： 子宫颈癌居女性恶性肿瘤发病率第二位，严重威胁着女性的生命和健康。实验发现，表观遗传学改变与人类多种肿瘤有着密切的关系，而肿瘤抑制基因DNA甲基化则是宫颈癌中常见的表观遗传学现象，与宫颈癌发生发展有着密不可分的联系。肿瘤抑制基因DNA甲基化研究将为宫颈癌发生机制研究，宫颈癌筛查及治疗提供新思路。

关键词: 宫颈肿瘤, 基因表达调控, 基因, 肿瘤抑制, 甲基化

Abstract: Cervical caner, the second most common gential tract malignancy in women, is a serious threat to women′s health and lives. Besides HR-HPV, some other factors are considered to be the mechanism of cervix neoplasms. This article reviewed the relationship of DNA methylation, especially the tumor-suppressing gene methylation and cervical cancer. Tumor-suppressing gene methylation is a common phenomenon in cervical cancer and is closely related with the carcinogensis. It provides a new way to the research of pathogenesis, screening and treatment of cervical cancer.

Key words: Uterine cervical neoplasms, Gene expression regulation, Genes, tumor suppressor, Methylation