国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (5): 318-321.

• 综述 • 上一篇    下一篇

早期宫颈癌前哨淋巴结及其微转移研究

王朝红, 李 立   

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  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-10-15 发布日期:2010-10-15

The Study on Sentinel Lymph Node Detection and It′s Micrometastasis in Early Cervical Cancer

WANG Zhao-hong, LI Li   

  1. Department of Gynecology, Fifth Affiliated Hospital, Guangxi Medical University, Liuzhou Municipal People′s Hospital, Liuzhou 545001, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-10-15 Online:2010-10-15

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摘要： 淋巴结转移是宫颈癌肿瘤细胞转移的最早特征，宫颈癌患者局部淋巴结状况直接影响患者的预后并决定着辅助治疗方案的制定。然而对患者盆腔所有淋巴结进行评估是一件十分繁杂的事情，前哨淋巴结（SLN）能反映整个盆腔淋巴结的转移状况，其研究使大多数早期宫颈癌患者避免不必要的盆腔淋巴结清扫术。目前常用的淋巴结识别方法有染料法、放射性核素示踪法及联合法。淋巴结微转移检测法（如：免疫组化法、连续切片法、鳞状细胞癌抗原检测及淋巴结HPV检测法等）能提高SLN的诊断准确性。

关键词: 宫颈肿瘤, 淋巴结, 前哨淋巴结活组织检查, 肿瘤转移

Abstract: As Lymph node metastasis is one of the earliest features of tumor cell spread in cervical cancer, assessment of the regional lymph nodes impacts the determining prognosis and planning adjuvant therapy directly. The sentinel lymph node（SLN） study, which could reflect the status of the entire pelvic lymphatic nodes, without removing all lymph nodes would spare most of patients with the loss of unaffected lymph nodes in early stage cervical cancer and give the chance of radical hysterectomy without pelvic lymphadenectomy. There are three techniques for sentinel lymph node identification; using blue dye alone, using 99Tcm colloid alone, or the combined method. Detecting micrometastases in lymph node with the use of immunohistochemistry IHC, the analysis of SCC-Ag levels or the determination of HPV status, may help to detect metastases of SLN.

Key words: Uterine cervical neoplasms, Lymph nodes, Sentinel lymph node biopsy, Neoplasm metastasis