国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (5): 336-339.

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Toll样受体2和4表达与原因不明复发性流产

翟洪波, 徐 键   

  1. <SPAN lang=EN-US style=
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-10-15 发布日期:2010-10-15

Expression of Toll Like Receptor 2 and 4 and Unexplained Recurrent Spontaneous Abortion

ZHAI Hong-bo, XU Jian   

  1. Women′s Hospital，School of Medicine，Zhejiang University, Hangzhou 310006, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-10-15 Online:2010-10-15

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摘要： 母胎界面的免疫耐受对维持正常妊娠至关重要。Toll样受体2（TLR2）和TLR4是机体重要天然免疫受体分子之一，TLR2识别肽聚糖，TLR4识别内毒素脂多糖。通过信号转导机制引起核因子κB（NF-κB）等转录因子的活化并调节肿瘤坏死因子α（TNF-α）、γ干扰素（IFN-γ）和白细胞介素12（IL-12）等的产生。越来越多的证据认为，这些细胞因子与不明原因复发性流产（URSA）Th1/Th2细胞因子失衡密切相关。探讨TLR2和TLR4在胎盘中的表达，及其在URSA中的可能作用。

关键词: 流产, 绒毛膜绒毛, 蜕膜, Toll样受体2, Toll样受体4

Abstract: Maternal-fetal interface of the immune tolerance is essential to maintain normal pregnancy. Toll like
receptor2（TLR2）and TLR4 are one of the important innate immune receptor molecules. TLR2 can recognize peptidoglycan, TLR4 can recognize lipopolysaccharide. Through the signal transduction mechanism, such as caused by NF-κB transcription factor activation and regulation of cytokines TNF-α, IFN-γ and IL-12 etc. A growing evidences show that these cytokines with unexplained recurrent spontaneous abortion（URSA） are closely related to Th1/Th2 cytokine imbalance. This paper discusses the possible role of the expression of TLR2 and TLR4 in the placenta, as well as in URSA in summary.

Key words: Abortion, Chorionic villi, Decidua, Toll-like receptor 2, Toll-like receptor 4