关键词:  铁；, 卵巢肿瘤；, 活性氧；, 谷胱甘肽过氧化酶；, 铁死亡；, 铁死亡诱导剂

Abstract: Ovarian cancer has the highest mortality among gynecologic malignancies. Studies in recent years have found that ferroptosis is closely related with ovarian cancer. Ferroptosis is an iron-dependent cell death mode different from apoptosis, necroiss and its particularity is lipid peroxide in cell membrane. The key to ferroptosis lies in the production of reactive oxygen species in Fenton reaction and the reduction of glutathione-dependant peroxidase 4. Currently, there are many inducers and inhibitors to regulate the ferroptosis. Using drugs to promote ferroptosis in ovarian cancer cells is a new treatment mode. The paper further discusses the mechanism of ferroptosis, drugs about ferroptosis and new developments of ferroptosis in ovarian cancer to provide new strategies for the treatment of ovarian cancer.

Key words: Iron；, Ovarian neoplasms；, Reactive oxygen species；, Glutathione peroxidase；, Ferroptosis；, Ferroptosis inducer