国际妇产科学杂志 ›› 2020, Vol. 47 ›› Issue (6): 694-698.

• 综述 • 上一篇    下一篇

子宫内膜异位症的药物治疗

彭丽娜,安春晓,张广美   

  1. 150001  哈尔滨医科大学附属第一医院妇产科
  • 收稿日期:2020-05-09 修回日期:2020-07-02 出版日期:2020-12-15 发布日期:2020-12-11
  • 通讯作者: 张广美,E-mail:guangmeizhang@126.com E-mail:guangmeizhang@126.com
  • 基金资助:
    国家自然科学基金面上项目(81971359);黑龙江省自然科学基金联合引导项目(LH2019H027);哈尔滨市应用技术研究与开发项目(2017AB9BS039)

Medical Treatment of Endometriosis

PENG Li-na, AN Chun-xiao, ZHANG Guang-mei   

  1. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
  • Received:2020-05-09 Revised:2020-07-02 Published:2020-12-15 Online:2020-12-11
  • Contact: ZHANG Guang-mei, E-mail: guangmeizhang@126.com E-mail:guangmeizhang@126.com

摘要: 子宫内膜异位症是一种雌激素依赖性疾病,好发于育龄期妇女,发病率高,治疗时间长,严重影响女性的身心健康和生活质量。目前,其发病机制尚未阐明,可用的治疗方法均有局限性,因此改进现有的治疗方案及寻找新的治疗药物成为研究热点。本文就子宫内膜异位症的传统药物和新兴药物进行阐述,并将重点放在对促性腺激素释放激素拮抗剂、芳香化酶抑制剂、选择性孕激素受体调节剂、选择性雌激素受体调节剂、抗血管生成药物以及抗氧化剂等新兴药物的介绍上,以期为子宫内膜异位症的研究及治疗提供新思路。

关键词: 子宫内膜异位症;, 促性腺素释放激素;, 促性腺激素释放激素拮抗剂;, 芳香化酶抑制剂;, 选择性孕激素受体调节剂;, 选择性雌激素受体调节剂;, 血管生成抑制剂;, 抗氧化剂

Abstract: Endometriosis is an estrogen dependent disease, which occurs frequently in women of childbearing age. The incidence rate is high, and the treatment time is long. It seriously affects the physical and mental health and quality of life of women. At present, its pathogenesis has not been clarified, and the available treatment methods have their limitations, so improving the existing treatment scheme and finding new treatment drugs have become a research hotspot. In this paper, the traditional medicine and emerging medicine of endometriosis are described. This article will focus on the introduction of emerging drugs such as gonadotropin-releasing hormone antagonist, aromatase inhibitors, selective progesterone receptor modulators, selective estrogen receptor modulators, anti-angiogenic agents and antioxidants, in order to provide new ideas for the research and treatment of endometriosis.

Key words: Endometriosis;, Gonadotropin-releasing hormone, Gonadotropin-releasing hormone antagonist;, Aromatase inhibitors;, Selective progesterone receptor modulators, Selective estrogen receptor modulators, Angiogenesis inhibitors;, Antioxidants