国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (5): 428-431.

• 综述 • 上一篇    下一篇

子宫内膜癌抑癌基因研究进展

张 佳,王永红   

  1. 030001 太原,山西医科大学第二临床医院妇产
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 王永红

Research Advancement in Tumor Suppressor Genes of Endometrial Carcinoma

ZHANG Jia，WANG Yong-hong   

  1. Department of Obstetrics and Gynecology，the Second Hospital of Shanxi Medical University，Taiyuan 030001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-10-15 Online:2011-10-15
  • Contact: WANG Yong-hong

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摘要： 子宫内膜癌是妇女常见的恶性肿瘤之一，发病率有逐年上升的趋势。随着分子生物学和免疫学的发展，关于子宫内膜癌分子水平的致癌机制研究日益深入，如癌基因、抑癌基因、DNA错配修复基因、雌激素代谢酶相关基因、甾体激素受体基因和细胞周期调控蛋白等。综述目前研究热点——抑癌基因的进展，为进一步探讨子宫内膜癌的发生发展、临床治疗及预后的判断提供重要依据。

关键词: 子宫内膜肿瘤, 基因, 肿瘤抑制, PTEN磷酸水解酶, 肿瘤抑制蛋白质p53, 基因, p16, 周期素依赖激酶抑制剂p27, 人类RUNT相关转录因子3, CHFR基因

Abstract: Endometrial cancer（EC）is one of the most common genital cancers in women worldwide，and the incidence increases year by year. With the development of immunology and molecular biology，there are more and more investigations in molecular mechanism of endometrial cancer，such as oncogenes，tumor suppressor genes，DNA mismatch repair genes，estrogen metabolic enzyme genes，steroid hormone receptor gene，cell cycle regulatory proteins，etc. In this study，the tumor suppressor genes of endometrial carcinoma were summarized，which might play an important role in tumor formation，development，treatment and prognosis.

Key words: Endometrial neoplasms, Genes, tumor suppressor, PTEN phosphohydrolase, Tumor suppressor protein p53, Genes, Cyclin-dependent kinase inhibitor p27, Human runt-related transcription factor 3, Checkpoint with FHA and ring finger genes