国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (5): 443-445.

• 论著 • 上一篇    下一篇

压力性尿失禁大鼠阴道壁及肛提肌组织TGFβ-3，Lamin，Relaxin的表达

张莹安,李兆艾   

  1. 030001 太原,山西省妇幼保健院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-10-15 发布日期:2011-10-15

The Expression of TGFβ-3，Lamin，Relaxin in the Vaginal Wall and Levator Ani of Rat Model of Stress Urinary Incontinence

ZHANG Ying-an，LI Zhao-ai   

  1. Department of Obstetrics and Gynecology，Shanxi Maternity and Children′s Health Hospital，Taiyuan 030001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-10-15 Online:2011-10-15

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摘要： 目的：探讨转化生长因子β-3（TGFβ-3）、层黏连蛋白（Lamin）和松弛素（Relaxin）mRNA的表达与压力性尿失禁（SUI）鼠发病的关系。方法：分别提取SUI模型鼠与正常大鼠（各8只）的阴道前壁及肛提肌组织，提取组织中RNA，采用反转录聚合酶链反应（RT-PCR）法分别测定上述3种因子含量的变化。结果：SUI大鼠与正常大鼠比较，阴道前壁和肛提肌中TGFβ-3 mRNA和Lamin mRNA的表达明显降低，Relaxin mRNA的表达明显增高，差异有统计学意义（均P＜0.05）。结论：SUI的发生与阴道前壁及肛提肌组织中TGFβ-3、Lamin表达减少、 Relaxin表达增多有关。

关键词: 尿失禁, 压力性, 转化生长因子β3, 层黏连蛋白, 松弛素

Abstract: Objective：To detect the relationship between mRNA expression of three factors（TGFβ-3，Lamin，
Relaxin）with stress urinary incontienece rats model. Methods：Seperately extrat the RNA in Levator ani and Vaginal of stress urinary incontienece rats model and normal rats（8 rats）. Use the RT-PCR method to detect the continence of Levator ani and Vaginal of stress urinary incontienece rats model and normal rats. Results：Compared with SUI rats and nomal rats，TGFβ-3 mRNA expression in levator ani and vagina are significant decreased（P＜0.05）. Lamin mRNA expression in levator ani and vagina are significant decreased（P＜0.05）. Relaxin mRNA expression in levator ani and vagina are significant higher（P＜0.05）. Conclusions：There is close relationship between occurrence of SUI and deficiency of TGFβ-3 and Lamin and increasing of Relaxin.

Key words: Urinary incontinence, stress, Transforming growth factor beta 3, Lamin, Relaxin