端粒长度与自然流产病因相关性研究现状

doi:10.12280/gjfckx.20210034

摘要/Abstract

摘要：

自然流产病因相关性研究一直是妇产科领域的研究热点。胚胎、母体、父亲及环境等各个因素对妊娠的影响在众多临床研究中得到证实,但仍有很多自然流产病例的原因无法得到解释。端粒是存在于真核细胞染色体线性DNA分子末端的帽样结构,参与维持染色体的稳定性和DNA复制的完整性。端粒在人类生殖过程中起着重要作用,端粒长度与配子及胚胎发育密切相关,与胚胎干细胞增殖潜能呈正相关,大多数研究证实自然流产以端粒缩短为特征,尤其是在非整倍体胚胎中,并且端粒长度与母体、父亲及环境因素均存在相关性。就端粒长度与自然流产病因的相关性研究进行综述,为自然流产的防治以及进一步研究提供理论依据与方向指导。

关键词: 端粒, 端粒缩短, 端粒稳态, 流产,自然, 危险因素

Abstract:

The study on the etiology of spontaneous abortion has always been a hot topic in the field of obstetrics and gynecology. The influence of various factors on pregnancy has been confirmed in numerous clinical studies, such as embryo, mother, father and environment, but there are still many cases of spontaneous abortion causes can not be explained. Telomeres are "cap" structures at the ends of linear DNA molecules in eukaryotic chromosomes, which are involved in maintaining chromosome stability and DNA replication integrity. Telomere plays an important role in the process of human reproduction, telomere length is closely related to the gamete and embryo development, positively correlated with the potential of embryonic stem cell proliferation. Most studies confirmed that spontaneous abortion is characterized by telomere shortening, especially in aneuploid embryos, and telomere length is in correlation with the mother, father and environmental factors. In this paper, the research on the correlation between telomere length and the etiology of spontaneous abortion is reviewed, to provide theoretical basis and direction guidance for the prevention and treatment of spontaneous abortion as well as further research.

Key words: Telomere, Telomere shortening, Telomere homeostasis, Abortion,spontaneous, Risk factors

白乐乐, 赵晓曦. 端粒长度与自然流产病因相关性研究现状[J]. 国际妇产科学杂志, 2021, 48(5): 512-516.

BAI Le-le, ZHAO Xiao-xi. Research Status of Correlation between Telomere Length and the Etiology of Spontaneous Abortion[J]. Journal of International Obstetrics and Gynecology, 2021, 48(5): 512-516.

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