妊娠滋养细胞疾病/肿瘤医学专有名词汇集和解读

doi:10.12280/gjfckx.20210530

摘要/Abstract

摘要：

随着妊娠滋养细胞疾病（gestational trophoblastic disease,GTD）/妊娠滋养细胞肿瘤（gestational trophoblastic neoplasia,GTN）诊治研究的不断深入,与其相关的病因、遗传学、分子生物学及临床研究等方面的论文逐步增多,因此GTD/GTN相关专有名词的正确使用至关重要。现结合国情,从妊娠滋养层细胞、GTD的分类、GTD组织分型、葡萄胎、葡萄胎后属有关的GTD/GTN、绒毛膜癌、GTD治疗、治疗评分后分度、人绒毛膜促性腺激素（human chorionic gonadotophin,hCG）分子家族及临床问题等九个分类进行详细阐述,汇集和解读了GTD/GTN相关的专有名词,便于妇产科医师对这些专有名词的理解和使用。

关键词: 妊娠滋养细胞疾病, 妊娠滋养细胞肿瘤, 葡萄胎, 葡萄胎,侵袭性, 绒毛膜癌

Abstract:

With the in-depth research into the diagnosis and treatment of gestational trophoblastic disease (GTD)/ gestational trophoblastic neoplasia(GTN), there are more and more papers on the etiology, genetics, molecular biology and clinical research of GTD/GTN. Therefore, the correct application of GTD/GTN-related proper nouns is crucial. According to our own national conditions, we explains nine categories in detail, including gestational trophoblastic cells, GTD classification, GTD tissue typing, hydatidiform mole, GTD/GTN of hydatidiform mole subordinates, choriocarcinoma, GTD treatment, post-treatment grading, hCG molecular family and clinical questions. Furthermore, this article collects and interprets the proper nouns related to GTD/GTN, which is convenient for obstetricians and gynecologists to understand and use these proper nouns.

Key words: Gestational trophoblastic disease, Gestational trophoblastic neoplasia, Hydatidiform mole, Hydatidiform mole,invasive, Choriocarcinoma

石一复, 李娟清. 妊娠滋养细胞疾病/肿瘤医学专有名词汇集和解读[J]. 国际妇产科学杂志, 2021, 48(5): 569-574.

SHI Yi-fu, LI Juan-qing. Collection and Interpretation of Medical Terms of Gestational Trophoblastic Disease/Neoplasia[J]. Journal of International Obstetrics and Gynecology, 2021, 48(5): 569-574.

参考文献 22

[1]	Lok C, van Trommel N, Massuger L, et al. Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease[J]. Eur J Cancer, 2020,130:228-240. doi: 10.1016/j.ejca.2020.02.011. doi: 10.1016/j.ejca.2020.02.011
[2]	Abu-Rustum NR, Yashar CM, Bean S, et al. Gestational Trophoblastic Neoplasia, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology[J]. J Natl Compr Canc Netw, 2019,17(11):1374-1391. doi: 10.6004/jnccn.2019.0053. doi: 10.6004/jnccn.2019.0053
[3]	Ngan H, Seckl MJ, Berkowitz RS, et al. Update on the diagnosis and management of gestational trophoblastic disease[J]. Int J Gynaecol Obstet, 2018,143(Suppl 2):79-85. doi: 10.1002/ijgo.12615. doi: 10.1002/ijgo.12615
[4]	李娟清, 杨建华, 石一复. 近年GTD/GTN诊治在EOTTD、NCCN和FIGO指南中的异同[J]. 中国计划生育和妇产科, 2021,13(1):24-27. doi: 10.3969/j.issn.1674-4020.2021.01.06. doi: 10.3969/j.issn.1674-4020.2021.01.06
[5]	Kurman RJ, Carcangiu ML, Herrington CS, et al. WHO classification of tumours of female reproduction organs (4th)[M]. Lyon:Int Agency for Research on cancer, 2014: 156.
[6]	石一复. 葡萄胎、绒毛膜癌及相关疾病[M]. 北京: 人民军医出版社, 2006:5-7,45-48,96-97,100-109,175-178,260-262,270-272.
[7]	向阳. 滋养细胞肿瘤学[M]. 北京: 人民卫生出版社, 2020:58,82-83,98-99,107- 109,275-276.
[8]	Chesley LC, Preece J. Hydatidiform mole, with special reference to recurrence and associated eclampsia[J]. Am J Obstet Gynecol, 1946,52:311-320. doi: 10.1016/s0002-9378(16)39842-8. doi: 10.1016/s0002-9378(16)39842-8
[9]	Endres RJ. Hydatidiform mole. Report of a patient with 5 consecutive hydatidiform moles[J]. Am J Obstet Gynecol, 1961,81(4):711-714.doi: 10.1016/s0002-9378(15)33517-1. doi: 10.1016/s0002-9378(15)33517-1
[10]	徐毓静. 葡萄胎一例报告[J]. 中华妇产科杂志, 1966,12(2):126.
[11]	丰有吉, 李荷莲. 妇产科学[M]. 北京: 人民卫生出版社, 2002: 310.
[12]	曹泽毅. 中华妇产科学[M]. 3版. 北京: 人民卫生出版社, 2014: 2438.
[13]	乐杰. 妇产科学[M]. 6版. 北京: 人民卫生出版社, 2004: 321.
[14]	Mack RB, Katz SM, Amenta PS. Choriocarcinoma of the kidney[J]. J Am Osteopath Assoc, 1992,92(6):799-802. doi: 10.7556/jaoa.1992.92.6.799. doi: 10.7556/jaoa.1992.92.6.799
[15]	Baergn RN, 刘伯宁, 范嫏娣. 人类胎盘病理学手册[M]. 天津: 天津科技翻译出版公司, 2008:261-266.
[16]	Essel KG, Bruegl A, Gershenson DM, et al. Salvage chemotherapy for gestational trophoblastic neoplasia: Utility or futility?[J]. Gynecol Oncol, 2017,146(1):74-80. doi: 10.1016/j.ygyno.2017.04.017. doi: 10.1016/j.ygyno.2017.04.017
[17]	石一复. 恶性滋养叶细胞PHA免疫化学疗法的探讨[J]. 中华肿瘤杂志, 1981,3(1):60.
[18]	叶大风, 石一复, 谢幸, 等. 单香菇多糖注射液对妊娠滋养细胞肿瘤化疗疗效和免疫功能的影响[J]. 实用肿瘤杂志, 2000,15(4):285-286. doi: 10.3969/j.issn.1001-1692.2000.04.033. doi: 10.3969/j.issn.1001-1692.2000.04.033
[19]	程红燕, 杨隽钧, 赵峻, 等. PD-1抑制剂治疗耐药复发妊娠滋养细胞肿瘤的初步探讨[J]. 中华妇产科杂志, 2020,55(6):390-394. doi: 10.3760/cma.j.cn112141-20191121-00636. doi: 10.3760/cma.j.cn112141-20191121-00636
[20]	You B, Bolze PA, Lotz JP, et al. Avelumab in Patients With Gestational Trophoblastic Tumors With Resistance to Single-Agent Chemotherapy: Cohort A of the TROPHIMMUN Phase II Trial[J]. J Clin Oncol, 2020,38(27):3129-3137. doi: 10.1200/JCO.20.00803. doi: 10.1200/JCO.20.00803
[21]	王丽娟, 冯凤芝, 林仲秋. 《2019 NCCN妊娠滋养细胞肿瘤临床实践指南(第一版)》解读[J]. 中国实用妇科与产科杂志, 2018,34(10):1125-1129. doi: 10.19538/j.fk2018100114. doi: 10.19538/j.fk2018100114
[22]	车艳辞, 戴淑真. 妊娠滋养细胞肿瘤人绒毛膜促性腺激素变化及其分子机制[J]. 中国实用妇科与产科杂志, 2011,27(9):658-660.