国际妇产科学杂志

国际妇产科学杂志 ›› 2022, Vol. 49 ›› Issue (2): 238-240.doi: 10.12280/gjfckx.20210655

• 妇科肿瘤研究:病例报告 • 上一篇    

极高危绒毛膜癌伴高钙血症一例并文献复习

程喆, 刘玉珍(), 张海凤   

  1. 261000 潍坊医学院（程喆）;潍坊医学院附属医院（刘玉珍,张海凤）
  • 收稿日期:2021-07-12 出版日期:2022-04-15 发布日期:2022-05-09
  • 通讯作者: 刘玉珍 E-mail:lyz0412@wfmc.edu.cn

Choriocarcinoma of Extremely High Risk with Hypercalcemia: A Case Report and Literature Review

CHENG Zhe, LIU Yu-zhen(), ZHANG Hai-feng   

  1. Weifang Medical University, Weifang 261000, Shandong Province, China (CHENG Zhe);Affiliated Hospital of Weifang Medical University, Weifang 261000, Shandong Province, China (LIU Yu-zhen, ZHANG Hai-feng)
  • Received:2021-07-12 Published:2022-04-15 Online:2022-05-09
  • Contact: LIU Yu-zhen E-mail:lyz0412@wfmc.edu.cn

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摘要：

绒毛膜癌是死亡率极高的一种妇科肿瘤,随着化疗药物在临床的合理应用,该病也获得了较满意的疗效。恶性肿瘤常伴有高钙血症的发生,但高钙血症在绒毛膜癌中的发生率极低。报告1例血人绒毛膜促性腺激素β亚单位（β-hCG）高达1 400 588.00 IU/L,且以高钙血症为突出表现的极高危绒毛膜癌（Ⅱ,13）患者的诊断与治疗过程,以降钙、化疗及手术相结合为主的方式对患者进行了成功救治。β-hCG降至正常范围后,患者拒绝行巩固化疗,密切随访6个月,未见病情反弹。通过对本病例的分析为绒毛膜癌的临床表现、诊断、治疗及随访提供一种新的思路。

关键词: 绒毛膜癌, 绒毛膜癌,非妊娠期, 绒毛膜促性腺激素,β亚单位,人, 高钙血症, 抗肿瘤联合化疗方案

Abstract:

Choriocarcinoma is a kind of gynecological tumor with extremely high mortality. With the rational application of chemotherapeutic drugs, choriocarcinoma can also get a satisfactory curative effect. Hypercalcemia is often associated with malignant tumors, but the incidence of hypercalcemia in choriocarcinoma is very low. We report a case of diagnosis and treatment of extremely high-risk choriocarcinoma (Ⅱ, 13) characterized by β-hCG up to 1 400 588.00 IU/L and hypercalcemia in blood. During the process of diagnosis and treatment, the patients were treated successfully by a combination of treatment about calcium reduction, chemotherapy and surgery. After β-hCG decreased to the normal range, the patient refused to receive consolidation chemotherapy. After 6 months of close follow-up, we don′t observe the disease bounces back. This case provides a new thinking for the clinical manifestation, diagnosis, treatment and follow-up of choriocarcinoma.

Key words: Choriocarcinoma, Choriocarcinoma,non-gestational, Chorionic gonadotropin,beta subunit,human, Hypercalcemia, Antineoplastic combined chemotherapy protocols