铂敏感复发性卵巢癌维持治疗药物的研究进展

doi:10.12280/gjfckx.20220004

摘要/Abstract

摘要：

卵巢癌作为妇科疾病中预后最差的恶性肿瘤,发病较为隐匿,临床早期诊断难度大。对卵巢癌患者行全面分期手术辅以铂类或紫杉醇的药物化疗的标准治疗方案后,复发率极高,复发患者在多次化疗后易产生铂类药物耐药性,治疗效果愈发低下。因此,如何减少肿瘤复发、延长患者生存时间、提高生存质量一直是临床治疗卵巢癌的难点。对于铂敏感复发性卵巢癌患者,需对其在进行手术加化疗后采取维持治疗,通过抗血管生成药物、多腺苷二磷酸核糖聚合酶[poly（ADP-ribose）polymerase,PARP]抑制剂等分子靶向药物维持患者化疗后疗效,以延长患者无进展生存期及延迟复发,改善生存率及生活质量。综述目前有关铂敏感复发性卵巢癌维持治疗的相关药物治疗方法,展望维持治疗在铂敏感复发性卵巢癌治疗中的应用前景。

关键词: 卵巢肿瘤, 抗肿瘤联合化疗方案, 抗血管生成药物, 贝伐单抗, 聚ADP核糖聚合酶类, 抗药性,肿瘤

Abstract:

As the worst prognosis malignant tumor in gynecological diseases, ovarian cancer is more insidious and difficult to be diagnosed in the early stage. The recurrence rate of ovarian cancer patients is extremely high after the standard treatment regimen of comprehensive staging surgical and chemotherapy with platinum or paclitaxel drugs. Patients with recurrence are prone to develop platinum resistance after multiple chemotherapy sessions, and the therapeutic effect is getting worse. Therefore, how to reduce tumor recurrence, prolong patients′ survival time and improve quality of life has always been a difficult point in clinical treatment of ovarian cancer. For patients with platinum-sensitive recurrent ovarian cancer, they need to be treated with maintenance therapy after surgery plus chemotherapy. Molecular targeted drug regimens such as anti-angiogenic drugs and poly (ADP-ribose) polymerase inhibitors are used to maintain the efficacy of post-chemotherapy treatment in order to prolong progression-free survival and delay recurrence, and improve survival and quality of life. The article reviews the current pharmacological approaches related to maintenance therapy for platinum-sensitive recurrent ovarian cancer and looks forward to the application of maintenance therapy in the treatment of platinum-sensitive recurrent ovarian cancer.

Key words: Ovarian neoplasms, Antineoplastic combined chemotherapy protocols, Antiangiogenic agents, Bevacizumab, Poly(ADP-ribose) polymerase, Drug resistance, neoplasm

常鑫, 韩璐. 铂敏感复发性卵巢癌维持治疗药物的研究进展[J]. 国际妇产科学杂志, 2022, 49(4): 382-387.

CHANG Xin, HAN Lu. Research Progress of Drugs for Maintenance Treatment for Platinum-Sensitive Recurrent Ovarian Cancer[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 382-387.

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