NLRP3炎症小体/IL-1β信号通路在子宫内膜异位症中的研究进展

doi:10.12280/gjfckx.20210484

摘要/Abstract

摘要：

子宫内膜异位症（endometriosis,EMs）常发生于育龄期妇女,组织学上表现为子宫内膜组织的腺体和间质存在于子宫以外的部位,临床上主要表现为疼痛（痛经、性交痛、慢性盆腔疼痛和尿痛等）和不孕。目前EMs的发病机制尚不十分清楚,但炎症反应被认为是EMs发病机制中的主要病理生理过程。NLR家族Pyrin域蛋白3（NOD-like receptor family,pyrin domain containing protein 3,NLRP3）参与炎症小体的组装,而后者是机体固有免疫系统的重要组成部分。近年有研究显示,EMs的发生发展过程中涉及NLRP3炎症小体的激活,从而增加白细胞介素1β（interleukin 1β,IL-1β）的产生,增强异位子宫内膜细胞的黏附、增殖、分化和侵袭。针对NLRP3炎症小体/IL-1β信号通路在EMs中的研究进展进行了综述,以期为EMs的诊断和治疗提供新的思路。

关键词: 子宫内膜异位症, NLR家族,热蛋白结构域包含蛋白3, 炎性体, 炎症, 白细胞介素1β

Abstract:

Endometriosis(EMs) often occurs in women of reproductive age, histologically characterized by the presence of glands and stroma of endometrial tissue outside the uterus. The main clinical manifestations are pain (dysmenorrhea, dyspareunia, chronic pelvic pain, dysuria, etc.) and infertility. Currently, the pathogenesis of EMs is still undefined, in which inflammation is believed to be the main pathophysiological process. NOD-like receptor family, pyrin domain containing protein 3(NLRP3) takes part in the assembly of the inflammasome which is an important role of the innate immune system. Recently, studies have shown that the activation of NLRP3 inflammasome is involved in the occurrence and development of EMs, thus elevating the level of interleukin 1β (IL-1β) and enhancing the adhesion, proliferation, differentiation and invasion of ectopic endometrial cells. In this paper, the research progress of NLRP3 inflammasome/IL-1β signaling pathway in EMs was reviewed in order to provide new strategies for the diagnosis and treatment of EMs.

Key words: Endometriosis, NLR family,pyrin domain-containing 3 protein, Inflammasomes, Inflammation, Interleukin-1beta

王诗瑶, 孙贇. NLRP3炎症小体/IL-1β信号通路在子宫内膜异位症中的研究进展[J]. 国际妇产科学杂志, 2021, 48(6): 691-695.

WANG Shi-yao, SUN Yun. Research Progress of NLRP3 Inflammasome/IL-1β Signaling Pathway in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2021, 48(6): 691-695.

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