国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (6): 380-382.

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慢性炎症机制与多囊卵巢综合征

陈子江, 徐兴华   

  1. 250021 济南袁山东省生殖医学重点实验室山东大学 附属省立医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-12-15 发布日期:2010-12-15
  • 通讯作者: 陈子江

Chronic Inflammation With Polycystic Ovarian Syndrome

CHEN Zi-jiang,XU Xing-hua   

  1. Shandong Provincial Key Laboratory of Reproductive Medicine,Center for Reproductive Medicine,Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-12-15 Online:2010-12-15
  • Contact: CHEN Zi-jiang

摘要: 多囊卵巢综合征(PCOS)是一种临床高度异质、病因复杂的疾病。近年研究发现,PCOS存在慢性炎症的病理生理过程,而且慢性炎症在PCOS远期并发症的发生发展中起重要作用。主要的慢性炎症因子,如C反应蛋白(CRP)、白细胞介素类(IL)、血浆纤溶酶原激活物抑制物1(PAI-1)、单核细胞趋化因子1(MCF-1)、肿瘤坏死因子(TNF)等在PCOS患者中有不同程度的升高,并且与PCOS患者的胰岛素抵抗、心血管疾病发病风险增高密切相关。

关键词: 多囊卵巢综合征, 炎症, 胰岛素抗药性, 心血管疾病, C反应蛋白质

Abstract: PCOS is a heterogeneous and complicated disease. Recently,it has been demonstrated that chronic inflammation participates in the pathphysiological progress of PCOS, which is closely related with the initiation and progression of long-term complications of PCOS. The elevated levels of main chronic inflammatory cytokines,including C-reactive protein (CRP), Interleukins(IL),Plasminogen Activator Inhibitor-1(PAI-1),Monocyte Chemotactic Factor-1(MCF-1) and Tumor Necrosis Factor(TNF),are associated with insulin resistance and cardiovascular diseases in women with PCOS.

Key words: Polycystic ovarian syndrome, Inflammation, Insulin resistance, Cardiovascular diseases, C-reactive protein