国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (6): 377-379.

• 述评 •    下一篇

子痫前期遗传学研究进展与展望

林其德， 叶太阳   

  1. 200127 上海交通大学医学院附属仁济医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-12-15 发布日期:2010-12-15
  • 通讯作者: 林其德

Progress and Prospect of the Genetic Study on Preeclampsia

LIN Qi-de，YE Tai-yang   

  1. Department of Obstetrics and Gynecology，Renji Hospital, School of Medicine，Shanghai Jiao Tong University，Shanghai 200127，Chin
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-12-15 Online:2010-12-15
  • Contact: LIN Qi-de

PDF (PC)

5208

被引次数

19

摘要： 遗传学因素在子痫前期的发病机制中起着重要的作用。通过着重介绍子痫前期易感基因和表观遗传学的研究进展，展望全基因组关联分析和表观遗传标志物研究在子痫前期遗传学病因研究中的作用，以及在子痫前期疾病诊断、治疗中的应用前景。

关键词: 先兆子痫, 疾病遗传易感性, 染色体, 基因, 基因组, 人

Abstract: Genetic factors play important roles in the pathogenesis of preeclampsia. The latest advances in the candidate genes and epigenetic research in preeclampsia were overviewed in this article . Meanwhile, the future application of genome-wide association study and epigenetic markers in the genetic etiologies research, diagnosis and treatment of preeclampsia were prospected.

Key words: Pre-eclampsia, Genetic predisposition to disease, Chromosomes, Genes, Genome, human