抗苗勒管激素与多囊卵巢综合征的关系

doi:10.12280/gjfckx.20220217

摘要/Abstract

摘要：

抗苗勒管激素（anti-müllerian hormone，AMH）在多囊卵巢综合征（polycystic ovary syndrome，PCOS）患者中表达明显升高，这可能与PCOS患者原始卵泡发育障碍有关。PCOS发病机制仍不明确，AMH可能是一个重要致病因素，其可通过神经内分泌机制、自噬机制等发挥调控作用。此外，AMH及其受体的基因改变也参与其中，组成PCOS的表观遗传学发病机制。AMH还可作为诊断PCOS的生化指标，截断值根据年龄、分型而有所调整。AMH与PCOS的不良妊娠结局也存在一定相关性，可作为早产的预测因子。综述AMH在PCOS发病机制、诊断及对妊娠结局影响等方面的研究进展，为妇产科临床工作提供理论依据。

关键词: 抗苗勒管激素, 多囊卵巢综合征, 卵泡, 自噬, 诊断, 妊娠结局

Abstract:

Anti-Müllerian hormone (AMH) is significantly elevated in patients with polycystic ovary syndrome (PCOS), which may be related to the primitive follicular development disorder of PCOS. The pathogenesis of PCOS is still unknown, and AMH may be an important pathogenic factor that plays a regulatory role through neuroendocrine mechanism and autophagy mechanism. In addition, the genetic changes of AMH and its receptor are also involved, which constitutes the epigenetic mechanism of PCOS. AMH can also be used as a biochemical index for the diagnosis of PCOS, the cutoff can be adjusted according to age and type. AMH is also correlated with the adverse pregnancy outcomes of PCOS, which can be used as a predictor of preterm birth. This paper reviews the research progress of AMH in the pathogenesis, diagnosis and impact on pregnancy outcomes of PCOS, so as to provide theoretical basis for the clinical work of obstetrics and gynecology.

Key words: Anti-mullerian hormone, Polycystic ovary syndrome, Ovarian follicle, Autophagy, Diagnosis, Pregnancy outcome

赵倩, 周抒. 抗苗勒管激素与多囊卵巢综合征的关系[J]. 国际妇产科学杂志, 2022, 49(6): 659-663.

ZHAO Qian, ZHOU Shu. Correlation between Anti-Müllerian Hormone and Polycystic Ovary Syndrome[J]. Journal of International Obstetrics and Gynecology, 2022, 49(6): 659-663.

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