HPV18阳性宫颈腺样基底细胞癌一例

doi:10.12280/gjfckx.20250114

摘要/Abstract

摘要：

宫颈腺样基底细胞癌（adenoid basal cell carcinoma，ABC）是一种罕见的宫颈癌，常与高危型人乳头瘤病毒感染密切相关，并伴有高级别鳞状上皮内病变，因缺乏特异性临床表现易漏诊，发病机制尚不明确而诊断困难。报告广州中医药大学第一附属医院收治的1例以发现宫颈病变3 d为主诉的绝经后宫颈ABC患者，因无生育要求行全子宫双附件切除术，随访至今无特殊不适。通过总结该疾病的病因、临床特征和诊治要点，以增进临床医生对该病的了解，提高诊疗水平。

关键词: 宫颈肿瘤, 癌, 基底细胞, 鳞状上皮内病变, 人乳头瘤病毒18, 诊断, 治疗

Abstract:

Cervical adenoid basal cell carcinoma (ABC) is a rare malignancy that is frequently associated with high-risk human papillomavirus(HPV) infection and often coexists with high-grade squamous intraepithelial lesion(HSIL). Due to its nonspecific clinical manifestations, ABC is prone to misdiagnosis, and its pathogenesis remains unclear, posing diagnostic challenges. This report presents a postmenopausal patient with cervical ABC who was admitted to the First Affiliated Hospital of Guangzhou University of Chinese Medicine with the chief complaint of cervical lesion 3 days prior. Given the patient′s lack of fertility desire, a total hysterectomy with bilateral salpingo-oophorectomy was performed. No postoperative complications or recurrence has been observed during follow-up. By summarizing the etiology, clinical characteristics, and key diagnostic and therapeutic considerations of this disease, this case aims to enhance clinicians′ understanding of cervical ABC and improve diagnostic accuracy and management strategies.

Key words: Uterine cervical neoplasms, Carcinoma, basal cell, Squamous intraepithelial lesions, Human papillomavirus 18, Diagnosis, Therapy

张茹雯, 曹蕾. HPV18阳性宫颈腺样基底细胞癌一例[J]. 国际妇产科学杂志, 2025, 52(4): 443-446.

ZHANG Ru-wen, CAO Lei. Cervical Adenoid Basal Cell Carcinoma with HPV18-Positivity: A Case Report[J]. Journal of International Obstetrics and Gynecology, 2025, 52(4): 443-446.

图/表 2

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