趋化因子及其受体在子痫前期发病机制中的作用

doi:10.12280/gjfckx.20251239

摘要/Abstract

摘要：

子痫前期（preeclampsia，PE）是一种严重且发病率较高的妊娠并发症，其发病机制复杂，涉及多重病理环节。研究表明，某些特定的趋化因子及其受体在PE孕妇与正常孕妇中的表达水平和功能存在显著差异，上述异常可通过多条信号通路协同调控，破坏母胎界面免疫耐受稳态，引发局部免疫微环境紊乱；同时干扰胎盘血管正常生成与重塑过程，并显著抑制滋养细胞的迁移、侵袭及浸润能力，进而导致子宫螺旋动脉重铸障碍、胎盘灌注不足与缺血缺氧性损伤、全身炎症反应过度激活以及血管内皮功能障碍，最终参与并介导PE的发生发展。综述近年趋化因子及其受体在PE发病机制中的作用研究进展，旨在为PE的诊治提供理论依据和新思路。

关键词: 炎症趋化因子类, 受体，趋化因子, 先兆子痫, 母胎界面, 免疫调节

Abstract:

Preeclampsia (PE) is a severe and highly prevalent pregnancy complication with a complex pathogenesis involving multiple pathological processes. Studies have demonstrated that the expression levels and functions of certain specific chemokines and their receptors are significantly different between pregnant women with PE and normal pregnant women. These abnormalities can be cooperatively regulated through multiple signaling pathways, disrupting the immune tolerance homeostasis at the maternal-fetal interface and inducing local immune microenvironment disturbances. Simultaneously, they interfere with normal placental vascular development and remodeling, and significantly inhibit the migration, invasion and infiltration capabilities of trophoblast cells. Consequently, they contribute to impaired spiral artery remodeling, placental hypoperfusion and ischemic-hypoxic injury, excessive activation of systemic inflammatory responses, and vascular endothelial dysfunction, ultimately participating in and mediating the onset and progression of PE. This review summarizes recent research advances regarding the role of chemokines and their receptors in the pathogenesis of PE, aiming to provide a theoretical basis and new insights for the diagnosis and treatment of PE.

Key words: Inflammatory chemokines, Receptors, chemokine, Pre-eclampsia, Maternal-fetal interface, Immune regulation

曹茹, 何碧薇, 杨星宇, 梁淑贞, 程蔚蔚. 趋化因子及其受体在子痫前期发病机制中的作用[J]. 国际妇产科学杂志, 2026, 53(3): 241-248.

CAO Ru, HE Bi-wei, YANG Xing-yu, LIANG Shu-zhen, CHENG Wei-wei. The Role of Chemokines and Their Receptors in the Pathogenesis of Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2026, 53(3): 241-248.

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