国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (1): 54-56.

• 论著 • 上一篇    下一篇

可逆性输卵管节育器干预大鼠子宫内膜异位症的实验研究

王哲，路芳，陈佃红，张平   

  1. 250011 济南，山东中医药大学附属医院（王哲，张平）；山东中医药大学（路芳，陈佃红）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-02-15 发布日期:2015-02-15
  • 通讯作者: 王哲

Experimental Research about Reversible Oviduct Synthetic Therapy for Endometriosis in Rats

WANG Zhe，LU Fang，CHEN Tian-hong，ZHANG Ping   

  1. Shandong University Hospital of Traditional Chinese Medicine，Jinan 250011，China（WANG Zhe，ZHANG Ping）；Shandong University of Traditional Chinese Medicine，Jinan 250014，China（LU Fang，CHEN Tian-hong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-02-15 Online:2015-02-15
  • Contact: WANG Zhe

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摘要： 目的：逆流法建立大鼠子宫内膜异位症（EMs）模型，观察可逆性输卵管节育器对大鼠EMs的预防作用。方法：30只大鼠随机分为3组，每组各10只，实验组逆流造模同时放置可逆性输卵管节育器，阴性对照组逆流造模，空白对照组不做处理。术后8周检测血清中抗子宫内膜抗体（EmAb）和CA125，观察组织形态学变化。结果：实验8周后3组大鼠血EmAb、CA125浓度差异有统计学意义（均P＜0.05）。阴性对照组血EmAb、CA125浓度高于空白对照组和实验组（均P＜0.05）。空白对照组无1例发病，阴性对照组8例发病，异位病灶体积（74.20±6.32）mm3，实验组1例发病，异位病灶体积为1.50 mm3。结论：可逆性输卵管节育器可预防大鼠EMs的发生。

关键词: 子宫内膜异位症, 避孕器械, 输卵管, 动物实验, 大鼠, Wistar, CA-125抗原

Abstract: Objective：To build the rat model of endometriosis by reflux method, observed the preventive effect of reversible oviduct synthetic on endometriosis in rats. Methods：The rats were divided into three groups randomly, experimental group（molding by reflux method and placement reversible oviduct synthetic）, negative control group（molding by reflux method）, blank control group（no processing）. Then tested EmAb and CA125 in serum, and observed the tissue morphological variations in eight weeks after operation. Results：There were difference in EmAb and CA125 in serum between three group (P＜0.05), and the negative control group was significantly higher than the experimental group and blank control group (P＜0.05). There were also no obvious difference in histomorphology between the experimental group and the blank group. Neither of them developed endometriosis. In histomorphology observation, there is none in blank control group, 8 cases in negative control group, ectopic lesions volume（74.20±6.30）mm3, 1 case in experimental group, volume for the onset of ectopic lesions 1.50 mm3. Conclusions：The reversible oviduct synthetic could prevent endometriosis in rats.

Key words: Endometriosis, Contraceptive devices, Fallopian tubes, Animal experimentation, Rats, Wistar