国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (3): 231-234.

• 综述 • 上一篇    下一篇

GDF-9的结构功能及其与卵巢疾病相关性研究

张成伟, 张新林, 王 勇   

  1. 210093 南京大学医学院组织学与胚胎学教研室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-06-15 发布日期:2012-06-15
  • 通讯作者: 王 勇

Structure Function of GDF-9 and the Association with Ovary Diseases

ZHANG Cheng-wei，ZHANG Xin-lin，WANG Yong   

  1. Key Laboratory of Medical Molecular Technology，Medical School of Nanjing University，Nanjing 210093，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-06-15 Online:2012-06-15
  • Contact: WANG Yong

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摘要： 作为转化生长因子β（TGF-β）超家族成员之一，生长分化因子9（GDF-9）被认为是卵泡生长发育和卵巢功能重要的调节因子，其通过多种途径调控优势卵泡的形成与卵母细胞的成熟。多囊卵巢综合征（PCOS）和卵巢功能早衰（POF）是育龄期妇女常见的生殖内分泌疾病，目前尚无有效的治疗方法。综述GDF-9的基因结构、功能、作用机制，及其与PCOS、POF相关性研究的最新进展。

关键词: 转化生长因子β, 多囊卵巢综合征, 卵巢功能早衰, 卵母细胞, 基因

Abstract: As a member of transforming growth factor-β superfamily， growth differentiation factor-9（GDF-9） is an important regulatory factor on development and functions of follicles. GDF-9 regulates the formation of dominant follicle and process of oocyte maturation. Polycystic ovary syndrome（PCOS） and premature ovarian failure （POF） are both common reproductive endocrine diseases in women of child-bearing age， but there is no effective treatment so far. This article summarizes structure function and mechanism of action of GDF-9 gene. In addition， the relationship between GDF-9 and ovary diseases is reviewed.

Key words: Transforming growth factor beta, Polycystic ovary syndrome, Ovarian failure, premature, Oocytes, Genes