国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (6): 423-426.

• 综述 • 上一篇    下一篇

ARHI与妇科恶性肿瘤的关系

杨海艳， 万小云   

  1. 310006 杭州，浙江大学医学院附属妇产科医院肿瘤科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-12-15 发布日期:2010-12-15
  • 通讯作者: 万小云

The Relationship Between ARHI and Gynecological Malignancy

YANG Hai-yan，WAN Xiao-yun   

  1. Department of Gynecologic Oncology，Women′s Hospital， School of Medicine, Zhejiang University, Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-12-15 Online:2010-12-15
  • Contact: WAN Xiao-yun

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摘要： 自噬是细胞通过自我消化实现大分子物质的循环再利用，维持细胞自身稳定的生物学过程。自噬活性的变化、自噬性细胞死亡与恶性肿瘤的发生、发展有关。自噬相关基因ARHI通过调节自噬活性，在肿瘤的发生、发展中发挥作用。ARHI调节自噬信号通路中某些关键激酶可能为肿瘤的治疗提供新的药物作用靶点

关键词: 自噬, 肿瘤, 基因, 细胞死亡, ARHI

Abstract: Autophagy is a biology process that recycle the macromolecular substances and maintain cell stability by self digestion. The change of autophagic activity, autophagic cell death are related to genesis and development of malignancy. ARHI, one of the autophagy related gene, may play a part in the occurrence and progress of tumor through regulating autophagic capacity. The key kinase in signaling pathways that ARHI regulates autophagic capacity may provide new drug targets for cancer treatment. This review summarized the present studies of ARHI, autophagy and their correlation with the occurrence and development of tumor.

Key words: Autophagy, Neoplasms, Genes, Cell death, ARHI