国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (6): 620-623.

• 综述 • 上一篇    下一篇

卵巢癌干细胞及其耐药性的研究进展

张 洁, 尧良清   

  1. 200011上海,复旦大学附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-12-15 发布日期:2012-12-15

Progress in Study on Cancer Stem Cell and Its Contribution to Drug Resistance of Ovarian Cancer

ZHANG Jie，YAO Liang-qing   

  1. Obstetrics and Gynecology Hospital of Fudan University， Shanghai 200011，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-12-15 Online:2012-12-15

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摘要： 卵巢癌是严重威胁女性生命健康的恶性肿瘤之一，早期症状不明显，化疗后易出现耐药性，治疗效果常不理想，患者预后不佳。近年出现的肿瘤干细胞假说成为抗肿瘤研究的又一热点。肿瘤干细胞具有自我更新并分化成普通肿瘤细胞的潜能，可能是肿瘤耐药和复发的根本原因。因此，从肿瘤干细胞出发，有望找到根除卵巢癌的方法。目前的研究已成功从卵巢癌中分离出具有干细胞特性的肿瘤细胞，但卵巢癌干细胞这一概念尚需更多的研究证实。

关键词: 肿瘤干细胞, 卵巢肿瘤, 抗药性, 肿瘤, 抗原, CD44

Abstract: Ovarian cancer， one of the most malignant and lethal cancers of the female reproductive system，is an
extremely aggressive disease associated with a lack of early symptoms，rapid progression to peritoneal metastases，easily formation of drug resistance，which might be the main reasons resulting to poor prognosis for patients. One emerging model for the development of drug-resistant tumors invokes a pool of selfrenewing malignant progenitors known as cancer initiating cells（CICs），which has been paid much attention in recent years. It is possible to find a method to eradicate ovarian cancer by targeting CICs. CICS have been isolated successfully from ovarian cancer in current research，but more evidence is needed to confirm the definition of CICs.

Key words: Neoplastic stem cells, Ovarian neoplasms, Drug resistance, neoplasm, Antigens, CD44