国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (6): 616-619.

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细胞因子信号抑制蛋白3与细胞迁移和侵袭的关系

涂飞霞,林 俊   

  1. 310006 杭州,浙江大学医学院附属妇产科医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-12-15 发布日期:2012-12-15

Relationship Between Suppressor of Cytokine Signaling-3 and Cell Migration and Invasion

TU Fei-xia，LIN Jun   

  1. Department of Obstetrics and Gynecology，Women's Hospital，School of Medicine，Zhejiang University，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-12-15 Online:2012-12-15

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摘要： 细胞因子信号抑制蛋白3（suppressor of cytokine signaling-3，SOCS-3）是一种常见的抑制性信号调节蛋白，参与负反馈调节Janus激酶/信号转导和转录激活因子（JAK/STAT）、促分裂素原活化蛋白激酶（MAPK）等多种重要信号通路，从而调控细胞因子、生长因子和激素对细胞的作用。细胞迁移和侵袭在一些生理过程和恶性肿瘤的发生发展中发挥了关键作用，SOCS-3可通过多种机制调节细胞的迁移及侵袭能力。

关键词: 细胞因子信号转导蛋白抑制因子, 细胞运动, 信号通路, 细胞侵袭

Abstract: Suppressor of cytokine signaling-3（SOCS-3），a common inhibitory molecule regulating many signaling pathways like JAK/STAT（Janus kinase/signal transducer and activator of transcription） and MAPK（mitogen-activated protein kinases），plays an important role in equating physical activities of cells when exposed to cytokines，growth factor and hormones. Cells capabilities of migration and invasion，which participate in tumor metastasis and many physiological processes，are wildly regulated by SOCS-3.

Key words: Suppressor of cytokine signaling proteins, Cell movement, Signaling pathway, Invasion