国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (3): 237-240.

• 综述 • 上一篇    下一篇

基因多态性与人乳头瘤病毒相关宫颈癌的研究

张洪秀,陈 燕,金 平   

  1. 730000 兰州大学第一临床医学院（张洪秀，陈 燕）；兰州大学第一医院妇产科（金 平）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-06-15 发布日期:2011-06-15
  • 通讯作者: 金 平

Research on Gene Polymorphism and Human Papilloma Virus Associated Cervical Cancer

ZHANG Hong-xiu，CHEN Yan，JIN Ping   

  1. The First Clinical College of Lanzhou University，Lanzhou 730000，China（ZHANG Hong-xiu，CHEN Yan）；Department of Obstetrics and Gynecology，the First Affiliated Hospital of Lanzhou University，Lanzhou 730000，China（JIN Ping）
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-06-15 Online:2011-06-15
  • Contact: JIN Ping

PDF (PC)

5345

被引次数

7

摘要： 宫颈癌是全球女性最常见的恶性肿瘤之一，居女性生殖器官恶性肿瘤首位。人乳头瘤病毒
（HPV）感染是宫颈癌的主要危险因素。HPV基因与宫颈组织基因相互融合，引起宫颈病变缓慢进展，从慢性炎症、低度不典型增生、高度不典型增生到癌变。从分子水平探索HPV基因与宫颈癌发病机制，寻找早期诊断、有效治疗和评估预后的新靶点是国内外学者研究的焦点。基于基因多态性及基因变异的基因诊断及治疗有望成为肿瘤治疗的新方向。

关键词: 宫颈肿瘤, 人乳头瘤病毒16, 多态性, 限制性片段长度, 细胞周期蛋白E, 趋化因子, CXC, 血管内皮生长因子A, 缺氧诱导因子1, 基因, P 53

Abstract: Cervical cancer is one of the most common cancer in female genital malignant tumor. And infection of HPV is considered as the main causes of cervical cancer. The gene of HPV fused with gene of cervical tissues，and thus leading to cervical lesions，progress from chronic inflammation，low grade dysplasia to high degree of dysplasia slowly，and then canceration.Currently，researchers of the world is devoting their mind to explore the pathogenesis of cervical cancer and gene of HPV，looking for early diagnosis，effective treatment and prognosis of new target gene.It has become a hot-spot to research gene mutation and polymorphisms in cancer from the molecular level in recent years，and gene diagnosis and treatment of cancer therapy is expected to become a new direction.Now，this paper reviewed genes involved in development of cervical carcinoma.

Key words: Uterine cervical neoplasms, Human papillomavirus 16, Polymorphism, restriction fragment length, Cyclin E, Chemokines, Vascular endothelial growth factor A, Hypoxia-inducible factor 1, Genes, P 53