国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (3): 234-236.

• 综述 • 上一篇    下一篇

微小RNA在妇科恶性肿瘤中的研究进展

李 翔,鲁艳明,张淑兰   

  1. 110004 沈阳，中国医科大学附属盛京医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-06-15 发布日期:2011-06-15

Progress in Study of MicroRNA in Gynecological Malignant Tumor

LI Xiang，LU Yan-ming，ZHANG Shu-lan   

  1. Department of Obstetrics and Gynecology， the Affiliated Shengjing Hospital of China Medical University，Shenyang 110004，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-06-15 Online:2011-06-15

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5185

被引次数

8

摘要： 微小RNA（microRNA，miRNA）是动、植物基因组中广泛存在的一类非编码单链小分子RNA，在转录后水平以完全或非完全互补的方式与其靶mRNA相结合，调节靶mRNA表达，从而影响生物学性状。研究发现，miRNA参与生命过程中一系列重要进程，参与人体生理或病理过程，与人类多种疾病密切相关。目前，关于miRNA在妇科恶性肿瘤中的研究仍处于起步阶段。大量研究发现，miRNA在肿瘤不同阶段表达不同，提示miRNA在恶性肿瘤的发生、诊断、治疗及预后起重要作用，但其具体作用机制仍不清楚，其临床应用价值仍有待进一步研究。

关键词: 微RNAs, 宫颈肿瘤, 子宫内膜肿瘤, 卵巢肿瘤, 癌

Abstract: MicroRNA is a kind of non-coded single stranded micromolecule RNA，generally existing in animal、plant genome.It integrates with its target mRNA by means of complete or incomplete complementary method in post-transcriptional level to regulate the expression of target mRNA，and then affects biological character.Update study and research show that，miRNA participates a series of important process in vital process，and also correlates closely with human disease. miRNA plays an important role of genesis，diagnosis，therapy and prognosis of malignant tumors.

Key words: MicroRNAs, Uterine cervical neoplasmas, Endometrial neoplasmas, Ovarian neoplasmas, Carcinoma