国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (3): 322-324.

• 论著 • 上一篇    下一篇

系统性红斑狼疮患者妊娠期细胞因子的水平及意义

刘恩令，周玉秀，柴连海   

  1. 063000 唐山，河北医科大学附属唐山市工人医院妇产科（刘恩令），免疫科（周玉秀），检验科（柴连海）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-06-15 发布日期:2015-06-15
  • 通讯作者: 刘恩令

The Detection and Significance of the Cytokines of Patients with Systemic Lupus Erythematosus during Pregnancy

LIU En-ling，ZHOU Yu-xiu，CHAI Lian-hai   

  1. Department of Obstetrics and Gynecology（LIU En-ling），Department of Rheumatology and Immunology（ZHOU Yu-xiu），Clinical Laboratory（CHAI Lian-hai），Tangshan Worker Hospital，Hebei Medical University，063000 Tangshan，Hebei Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-06-15 Online:2015-06-15
  • Contact: LIU En-ling

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摘要： 目的：探讨系统性红斑狼疮（SLE）患者妊娠期细胞因子的改变，为临床检测及治疗提供指导。方法：选取单胎妊娠合并SLE患者53例，并选取同期正常单胎妊娠妇女50例作为对照。收集所有对象的妊娠早期（≤12周）及妊娠晚期（≥28周）时血清标本，采用酶联免疫吸附试验检测血清白细胞介素1α（IL-1α）、IL-1β、IL-2、IL-6、IL-8、IL-10、IL-12p70、γ干扰素（IFN-γ）和肿瘤坏死因子α（TNF-α）。结果：对照组妊娠晚期Th1型细胞因子（IL-1α，IL-1β，IL-2，IL-8，IL-12p70，IFN-γ和TNF-α）较妊娠早期明显减少（均P＜0.05），而Th2型细胞因子（IL-6、IL-10）却没有明显变化（P＞0.05）。SLE组Th1型细胞因子中只有IL-1α在妊娠晚期明显下降（P=0.001），其他Th1型细胞因子和Th2型细胞因子均无明显改变（P＞0.05）。在妊娠早、晚期，SLE组的IL-10水平均显著高于对照组，差异有统计学意义（均P=0.000）。对照组妊娠晚期IFN-γ/IL-6比值明显低于妊娠早期，差异有统计学意义（0.65±0.22 vs. 1.05±0.17，t=10.17，P=0.000），而SLE组妊娠晚期IFN-γ/IL-6比值与妊娠早期相比差异无统计学意义（0.53±0.16 vs. 0.48±0.18，t=1.51，P=0.067）。对照组妊娠早、晚期的IFN-γ/IL-10比值均显著高于SLE组，差异有统计学意义（2.16±0.47 vs. 0.79±0.13，t=19.91，P=0.000；3.35±0.96 vs. 1.26±0.26，t=14.89，P=0.000）。结论：SLE患者妊娠期细胞因子的变化是复杂多样的，IL-10水平显著高于对照组，妊娠期监测细胞因子对确定SLE疾病活动和判断病情变化有着重要指导意义。

关键词: 红斑狼疮, 系统性, 孕妇, 细胞因子类

Abstract: Objective： To explore the changes of cytocines in pregnancy for systemic lupus erythematosus and guide the clinical treatment. Methods: We select 53 single pregnancy patients with systemic lupus erythematosus as study group and 50 normal single pregnancy pregnant women as control group. The serum IL-1α，IL-1β，IL-2，IL-6，IL-8，IL-10，IL-12p70，IFN-γ and TNF-α were detected by using enzyme-linked immunosorbent assay. Results: The Th1 cytokines （IL-1α，IL-1β，IL-2，IL-8，IL-12 p70，IFN-γ and TNF-α） significantly decreased in late pregnancy for healthy women comparing with the early pregnancy （P＜0.05）. But IL-6 and IL-10 were not obvious changes （P＞0.05）. In SLE patients，Th1 type only IL-1α decreased obviously in late pregnancy（P=0.001），and other Th1 cytokines and Th2 cytokines （IL-6，IL-10） had no obvious changes. IL-10 of SLE patients in early and late pregnancies were significantly higher than that of control group （both P=0.000）. In late pregnancy for control group，the ratio of IFN -γ/IL-6 was significantly lower than that of early pregnancy （0.65±0.22 vs. 1.05±0.17，t=10.17，P=0.000）. The IFN-γ/IL-6 ratio in SLE patients had no significant difference（0.53±0.16 vs. 0.48±0.18，t=1.51，P=0.067）. The ratio of IFN -γ/IL - 10 in early pregnancy and late pregnancy for healthy women were significantly higher than those of SLE patients （2.16±0.47 vs. 0.79±0.13，t=19.91，P=0.000；3.35±0.96 vs. 1.26±0.26，t=14.89，P=0.000）. Conclusions: The changes of cytokines in patients with systemic lupus erythematosus during pregnancy are complex and diverse. The level of IL-10 in SLE patients was significantly higher than that of control group. The monitoring of cytokines in SLE during pregnancy helps to determine disease activity and judgement condition change in SLE.

Key words: Lupus erythematosus, systemic, Pregnant women, Cytokines