国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (4): 466-469.

• 综述 • 上一篇    下一篇

人乳头瘤病毒疫苗预防宫颈癌的应用

夏巧凡，何莲芝   

  1. 241001 安徽省芜湖市，皖南医学院第一附属医院弋矶山医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 何莲芝

Application of HPV Vaccines in Preventing Development of the Cervical Cancer

XIA Qiao-fan，HE Lian-zhi   

  1. Department of Obstetrics and Gynecology，Yijishan Hospital，Wannan Medical College，Wuhu 241001，Anhui Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-08-15 Online:2015-08-15
  • Contact: HE Lian-zhi

PDF (PC)

5357

被引次数

10

摘要： 宫颈癌严重危害女性健康，现已明确人乳头瘤病毒（HPV）感染是其主要致病因素。HPV通过机体的细微损伤入侵，HPV E6和E7癌蛋白中的1种或2种持续表达是高危型HPV感染致瘤的关键所在，检测高危型HPV感染及病毒癌蛋白仍不能有效预防宫颈癌。研究者们正着手研制针对HPV的病毒疫苗，从源头预防HPV感染，以期实现宫颈癌的一级预防。目前已有针对HPV16/18型的二价疫苗Cervarix和针对HPV16/18/11/6型的四价疫苗Gardasil的认证上市，预防性HPV疫苗已在全球范围内推广使用并取得显著效果。新一代预防性HPV疫苗在解决疫苗的成本、持久性和广谱免疫问题上取得突破性进展，宫颈癌有望成为人类抗肿瘤史上第一个可以预防的癌症。综述近年HPV的生物学特性、致病机制及预防性HPV疫苗的应用研究与现状。

关键词: 乳头状瘤病毒疫苗, 宫颈肿瘤, 一级预防

Abstract: Cervical cancer causes serious damage to women′s health. It is clear that human papillomavirus （HPV） infection is the major pathogenic factor. HPV invades the organism by subtle injures. When E6 or E7 oncoprotein is continous expression in the epithelial tissue, high-risk HPV infections contribute to tumorigenicity. Detection of high-risk HPV infection and virus oncoprotein still cannot prevent cervical cancer effectively. Researchers begin to develop a vaccine against the HPV virus, and to prevent HPV infections from the sources, hoping to achieve the primary prevention of cervical cancer. Currently bivalent vaccine Cervarix against HPV 16/18 and quadrivalent vaccine Gardasil against HPV 16/18/11/16 have been approved for marketing. Prophylactic HPV vaccines have been used widely on a global scale and obtained significant effect. A new generation of prophylactic HPV vaccines have made a breakthrough in solving problems including cost, persistence and broad-spectrum immune. Cervical cancer is expected to become the first preventable cancer in the history of human anti-tumor. This review concentrates on the biological characteristics and pathogenic mechanism of HPV and the current application and situation of prophylactic HPV vaccines.

Key words: Papillomavirus vaccines, Uterine cervical neoplasms, Primary prevention